Peripheral Effects of Endotoxin on Insulin Resistance

NCT ID: NCT00929136

Last Updated: 2010-10-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-30

Study Completion Date

2010-05-31

Brief Summary

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The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Endotoxin

Group Type EXPERIMENTAL

USP endotoxin

Intervention Type BIOLOGICAL

Continuous intra-arterial infusion

Interventions

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USP endotoxin

Continuous intra-arterial infusion

Intervention Type BIOLOGICAL

Other Intervention Names

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USP Endotoxin, LOT: G3E069

Eligibility Criteria

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Inclusion Criteria

1. Normal health
2. 22 \< BMI \< 28
3. Written Informed Concent

Exclusion Criteria

1. Any disease
2. Any use of medication
3. Recent immobilization of a lower extremity
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role lead

Responsible Party

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University of Aarhus

Principal Investigators

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Mads Buhl, M.D.

Role: PRINCIPAL_INVESTIGATOR

Medical Department M (Endocrinology and Diabetes), Ã…rhus University Hospital, Denmark

Niels Moller, M.D., professor, Dmsc

Role: STUDY_DIRECTOR

Medical Department M (Endocrinology and Diabetes), Aarhus University Hospital, Denmark

Locations

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The Medical Research Laboratories, Dept. M, Aarhus University Hospital

Aarhus, , Denmark

Site Status

Countries

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Denmark

References

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Buhl M, Bosnjak E, Vendelbo MH, Gjedsted J, Nielsen RR, K-Hafstrom T, Vestergaard ET, Jessen N, Tonnesen E, Moller AB, Pedersen SB, Pilegaard H, Bienso RS, Jorgensen JO, Moller N. Direct effects of locally administered lipopolysaccharide on glucose, lipid, and protein metabolism in the placebo-controlled, bilaterally infused human leg. J Clin Endocrinol Metab. 2013 May;98(5):2090-9. doi: 10.1210/jc.2012-3836. Epub 2013 Mar 29.

Reference Type DERIVED
PMID: 23543661 (View on PubMed)

Other Identifiers

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Aarhus University Hospital

Identifier Type: -

Identifier Source: org_study_id