Investigations Regarding B-cell Subsets in Humans

NCT ID: NCT00926692

Last Updated: 2015-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

249 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-04-30

Study Completion Date

2014-07-31

Brief Summary

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The aim of this research is to define the human equivalent of mouse B1 cells.

Detailed Description

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The specific aim of this research project is to define the human equivalent of mouse B1 cells. This will be done by evaluating IgM secretion, surface markers, functional characteristics, V gene usage, N-region addition, and phosphorylation status of intracellular proteins, gene expression, sequencing of immunoglobulin genes, determination of antigenic specificity, replication history, and response to different stimuli.

The goal of this project is to begin to the translation of decades of basic science research and research in the mouse model into the human system. It is believed that properly defining this B cell subset in humans will lead to better therapeutics, prognostics and prevention for a number of disease including infections, autoimmune disease, and cancer.

Conditions

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Healthy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy Subjects

All subjects are considered healthy

Blood draw

Intervention Type OTHER

Subject will have blood draw.

Interventions

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Blood draw

Subject will have blood draw.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subject is considered by the physician to be a healthy adult.

Exclusion Criteria

* Subject is under the age of 18
* Subject has an infection or is currently ill
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Northwell Health

OTHER

Sponsor Role lead

Responsible Party

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Daniel Griffin

Fellow Infectious Diseases

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Daniel Griffin, M.D.

Role: PRINCIPAL_INVESTIGATOR

Feinstein Institute for Medical Research

Locations

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Feinstein Institute for Medical Research

Manhasset, New York, United States

Site Status

Countries

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United States

Other Identifiers

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GCRC 0266

Identifier Type: -

Identifier Source: org_study_id

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