Evaluation of the Cryotherapy in the Prevention of Nails Toxicity Induced by Taxotere® in Breast or Prostate Cancer

NCT ID: NCT00925418

Last Updated: 2011-09-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

168 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-09-30

Study Completion Date

2011-07-31

Brief Summary

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Taxotere® can induce nails changes like dyschromia, hematoma, lines of Beau-Reil (signing the stop of the epithelial proliferation), abscess, or pain. In this context, this randomized, monocentric phase III trial evaluates the cryotherapy, using frozen glove, in the prevention of nails toxicity induced by Taxotere® in patient treated for breast or prostate cancer.

Primary objective:

Demonstrate a reduction of the nails toxicity using frozen glove during chemotherapy with Taxotere®.

Secondary objectives:

Analysis of time of protection against onycholysis Estimation of the efficiency of cryotherapy, and impact on quality of life Tolerance and compliance of the frozen glove

Detailed Description

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Conditions

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Breast Neoplasms Prostate Cancer Nail Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Without Glove

Patients do not use frozen glove during chemotherapy with Taxotere®

Group Type NO_INTERVENTION

No interventions assigned to this group

With Glove

Patients use frozen glove during chemotherapy with Taxotere®

Group Type EXPERIMENTAL

Frozen Glove

Intervention Type PROCEDURE

Using frozen glove during chemotherapy with Taxotere®

Interventions

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Frozen Glove

Using frozen glove during chemotherapy with Taxotere®

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with hormono-resistant breast cancer or metastatic prostate cancer treated by chemotherapy with Taxotere®.
* Patients aged 18 and older
* Nail toxicity \< grade 2 (CTC-AE version 3.0)
* Informed patients with signed consent

Exclusion Criteria

* History of treatment with taxane
* Raynaud syndrome
* Distal metastasis in superior extremity
* Nail diseases
* Distal arteriopathy
* Cold intolerance
* Peripheral neuropathy\>=2
* Pregnancy, breast feeding
* Unable to give informed consent
* Unable to have a medical follow-up for social, geographical, family or psychological reasons
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Institut Paoli-Calmettes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Carole TARPIN, MD

Role: PRINCIPAL_INVESTIGATOR

Institut Paoli-Calmettes

Locations

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Institut PAOLI-CALMETTES

Marseille, , France

Site Status

Countries

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France

Related Links

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http://www.institutpaolicalmettes.fr

Official web site of the sponsor

Other Identifiers

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CRYO 1/IPC 2005-007

Identifier Type: -

Identifier Source: org_study_id

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