Evaluate Saxagliptin in Adult Indian Patients With Type 2 Diabetes Inadequate Glycemic Control

NCT ID: NCT00918879

Last Updated: 2011-09-26

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

213 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-05-31

Study Completion Date

2010-07-31

Brief Summary

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Saxagliptin is a new investigational medication being developed for treatment of type 2 diabetes. This study is designed to evaluate the efficacy and safety in adult Indian patients with inadequate glycaemic control with diet and exercise.

Detailed Description

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Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Saxagliptin

Group Type EXPERIMENTAL

Saxagliptin

Intervention Type DRUG

Oral tablet, once daily for 24 weeks

2

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Oral tablet, once daily for 24 weeks

Interventions

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Saxagliptin

Oral tablet, once daily for 24 weeks

Intervention Type DRUG

Placebo

Oral tablet, once daily for 24 weeks

Intervention Type DRUG

Other Intervention Names

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Onglyza

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with Type 2 diabetes
* Patients should be drug naïve ie, not received medical treatment for diabetes
* HbA1c ≥ 7.2% and ≤10.0% (at enrolment), HbA1c ≥ 7.0% and ≤10.0% (at randomization)

Exclusion Criteria

* Insulin therapy within one year of enrolment (with the exception of insulin therapy during a hospitalization or use in gestational diabetes)
* Type 1 diabetes,history of ketoacidosis or hyperosmolar non-ketonic koma
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role collaborator

AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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AstraZeneca

Principal Investigators

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Peter Ohman, MD, PhD

Role: STUDY_DIRECTOR

AstraZeneca, Wilmington, USA

Deborah Price, MSc

Role: STUDY_CHAIR

AstraZeneca, Wilmington, USA

Locations

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Research Site

Gujarat, Ahmedabad, India

Site Status

Research Site

Karnataka, Bangalore, India

Site Status

Research Site

Tamil Nadu, Chennai, India

Site Status

Research Site

Tamil Nadu, Coimbatore, India

Site Status

Research Site

Andhra Pradesh, Hyderabad, India

Site Status

Research Site

Madhya Pradesh, Indore, India

Site Status

Research Site

Haryāna, Karnal, India

Site Status

Research Site

Kerala, Kochi, India

Site Status

Research Site

Maharashtra, Pune, India

Site Status

Countries

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India

References

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Perl S, Cook W, Wei C, Iqbal N, Hirshberg B. Saxagliptin Efficacy and Safety in Patients With Type 2 Diabetes and Moderate Renal Impairment. Diabetes Ther. 2016 Sep;7(3):527-35. doi: 10.1007/s13300-016-0184-9. Epub 2016 Jul 11.

Reference Type DERIVED
PMID: 27402391 (View on PubMed)

Other Identifiers

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D1680C00008

Identifier Type: -

Identifier Source: org_study_id