A Study to Evaluate Antiviral Activity of Darunavir + Ritonavir in HIV-1 Infected Adolescents

NCT ID: NCT00915655

Last Updated: 2012-09-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-07-31
• Study Completion Date: 2011-03-31

Brief Summary

The purpose of this study is to evaluate pharmacokinetics (what body does to medication), safety, tolerability, and efficacy (effectiveness) of darunavir with low-dose ritonavir (DRV/rtv) administered once daily, in combination with an investigator-selected background regimen consisting of other antiretrovirals (ARVs) ie, 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), in treatment-naive (never treated before) HIV-1 infected adolescents aged from 12 to <18 years and weighing at least 40 kg.

Detailed Description

This is an open-label (all people know the identity of the intervention), single-arm, Phase II study to evaluate the pharmacokinetics, safety, tolerability, and efficacy of darunavir/ritonavir (DRV/rtv) administered once daily, in combination an investigator-selected background regimen (2 NRTIs), in treatment-naive HIV-1 infected adolescents over 48 weeks. A total of 12 patients will be enrolled in this study. Patients will be considered treatment-naive if they have never received treatment with an ARV medication, including both investigational as well as commercially available ARVs indicated for the treatment of HIV-infection and ARVs for the treatment of hepatitis B infection with anti-HIV activity. The investigator-selected background regimen will consist of 2 NRTIs, either zidovudine/lamivudine or abacavir/lamivudine, whichever is approved and marketed or considered local standard of care for adolescents aged from 12 to <18 years in a particular country. The study will consist of a 4-week screening period, a 48-week treatment period, and a 4-week follow-up period. Safety, efficacy, resistance (reduction in effectiveness of a medication), pharmacokinetic analyses, and pharmacodynamic (what medication does to body) analyses will be performed at Week 24 (primary analysis) and Week 48 (final analysis). Patients who will complete the 48 weeks of treatment with DRV/rtv and who will continue to benefit from this treatment, will have the opportunity to continue this treatment until they no longer benefit from the medication, until DRV is commercially available or can be accessed from another source (eg, access program, government program) or until the development program is discontinued.

Conditions

HIV-1 Infection

Keywords

HIV Infections; TMC114-TiDP29-C230; TMC114-C230; TMC114; HIV-1; Darunavir; Ritonavir; NRTI; Treatment Naive

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

DRV/rtv (darunavir/ritonavir)

Patients will receive darunavir tablets 2 x 400 mg in combination with ritonavir capsule 100 mg once daily for 48 weeks along with 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) ie, either zidovudine/lamivudine or abacavir/lamivudine

Group Type: EXPERIMENTAL

darunavir

Intervention Type: DRUG

Type=exact number, unit=mg, number=400, formulation=tablet, route=oral. 2 tablets of darunavir administered once daily for 48 weeks

ritonavir

Intervention Type: DRUG

Type=exact number, unit=mg, number=100, formulation=capsule, route=oral. 1 capsule of ritonavir administered once daily for 48 weeks

zidovudine

Intervention Type: DRUG

NRTI (zidovudine) administered as per approved, marketed, or considered local standard of care for patients aged between 12 and \< 18 years in a particular country

lamivudine

Intervention Type: DRUG

NRTI (lamivudine) administered as per approved, marketed, or considered local standard of care for patients aged between 12 and \< 18 years in a particular country

abacavir

Intervention Type: DRUG

NRTI (abacavir) administered as per approved, marketed, or considered local standard of care for patients aged between 12 and \< 18 years in a particular country

Interventions

darunavir

Type=exact number, unit=mg, number=400, formulation=tablet, route=oral. 2 tablets of darunavir administered once daily for 48 weeks

Intervention Type: DRUG

ritonavir

Type=exact number, unit=mg, number=100, formulation=capsule, route=oral. 1 capsule of ritonavir administered once daily for 48 weeks

Intervention Type: DRUG

zidovudine

NRTI (zidovudine) administered as per approved, marketed, or considered local standard of care for patients aged between 12 and \< 18 years in a particular country

Intervention Type: DRUG

lamivudine

NRTI (lamivudine) administered as per approved, marketed, or considered local standard of care for patients aged between 12 and \< 18 years in a particular country

Intervention Type: DRUG

abacavir

NRTI (abacavir) administered as per approved, marketed, or considered local standard of care for patients aged between 12 and \< 18 years in a particular country

Intervention Type: DRUG

Other Intervention Names

DRV; rtv

Eligibility Criteria

Inclusion Criteria

• Patients with a documented HIV-1 infection
• Body weight from at least 40 kg at screening
• Screening plasma HIV-1 RNA >= 1000 copies/mL
• Parents or legal representative and trial patients (where appropriate, depending on age and local regulation) willing and able to give consent and assent
• General medical condition, in the investigator's opinion, does not interfere with the assessments and the completion of the trial
• Able to swallow darunavir tablets (400 mg) and ritonavir capsules (100 mg)

Exclusion Criteria

• Patients with presence of any currently active conditions included in the listing of World Health Organisation (WHO) Clinical Stage 4
• Any condition (including, but not limited to, alcohol and drug use), which, in the opinion of the investigator, could compromise the patient's safety or adherence to the trial protocol
• Previous or current use of antiretrovirals (ARVs)
• Primary or acute HIV infection
• Use of any investigational agents within 30 days prior to screening
• Use of disallowed concomitant therapy
• Pregnant or breast-feeding
• Female patient of childbearing potential without use of effective non-hormonal birth control methods or not willing to continue practicing these birth control methods for at least 30 days after the end of the treatment period
• Patients with clinical or laboratory evidence of significantly decreased hepatic function or decompensation (ie, liver insufficiency), irrespective of liver enzyme levels
• Any active clinically significant disease (eg, cardiac dysfunction, pancreatitis, acute viral infection) or findings during screening of medical history or physical examination that are expected to compromise the patient's safety or outcome in the trial

• Minimum Eligible Age: 12 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tibotec Pharmaceutical Limited

INDUSTRY

Sponsor Role: collaborator

Tibotec Pharmaceuticals, Ireland

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Tibotec Pharmaceuticals Clinical Trial

Role: STUDY_DIRECTOR

Tibotec Pharmaceutical Limited

Locations

Memphis, Tennessee, United States

Paris, , France

Dublin, , Ireland

Esplugues de Llobregat, , Spain

Madrid, , Spain

Kiev, , Ukraine

Birmingham, , United Kingdom

Bristol, , United Kingdom

Stoke-on-Trent, , United Kingdom

Countries

United States; France; Ireland; Spain; Ukraine; United Kingdom

Other Identifiers

TMC114-TiDP29-C230

Identifier Type: OTHER

Identifier Source: secondary_id

2008-004631-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

CR016312

Identifier Type: -

Identifier Source: org_study_id