Pharmacokinetics of Tacrolimus in Liver Transplantation Patients Treated With Prograf and Modified Release Tacrolimus

NCT ID: NCT00909571

Last Updated: 2010-04-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2010-03-31

Brief Summary

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Tacrolimus pharmacokinetics study in primary living donor liver transplantation patients with Tacrolimus based immunosuppressive regimens.

Detailed Description

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To describe the pharmacokinetics of Tacrolimus when administered as two different doses of modified release formulation FK506E(MR4) combined with Prograf injection in patients undergoing primary living donor liver transplantation based on the single center (Asan Medical Center) standard protocol regimen.

Conditions

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Liver Transplantation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Study Groups

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1. FK506E high dose group

Group Type EXPERIMENTAL

FK506E (modified release tacrolimus)

Intervention Type DRUG

oral

Prograf (tacrolimus)

Intervention Type DRUG

injection

2. FK506E low dose group

Group Type EXPERIMENTAL

FK506E (modified release tacrolimus)

Intervention Type DRUG

oral

Prograf (tacrolimus)

Intervention Type DRUG

injection

Interventions

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FK506E (modified release tacrolimus)

oral

Intervention Type DRUG

Prograf (tacrolimus)

injection

Intervention Type DRUG

Other Intervention Names

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MR4, modified release Tacrolimus FK506 tacrolimus

Eligibility Criteria

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Inclusion Criteria

* Patients receiving a primary partial liver graft from a living donor
* Patients must receive the first dose of Tacrolimus after surgery and are expected to be maintained on Tacrolimus throughout the study

Exclusion Criteria

* Patients receiving a multi-organ transplantation or having previously received an organ transplantation
* Patients receiving an auxiliary graft or in whom a bio-artificial liver has been used
* Patients allergic or intolerant to macrolide antibodies or Tacrolimus
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Astellas Pharma Korea, Inc.

INDUSTRY

Sponsor Role collaborator

Astellas Pharma Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Astellas Pharma, Inc

Principal Investigators

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Use Central Contact

Role: STUDY_CHAIR

Astellas Pharma Korea, Inc.

Locations

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Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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MR-08-04-KOR

Identifier Type: -

Identifier Source: org_study_id

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