Effect of Repeated Dosing of Naproxcinod on Renal Hemodynamic and on Sodium Balance in Healthy Volunteers Before and After a Single Dose of Furosemide

NCT ID: NCT00909519

Last Updated: 2011-06-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 31 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-01-31
• Study Completion Date: 2009-04-30

Brief Summary

This phase 1 study is an 8-day treatment period, randomized, controlled, double-blind, 3 parallel-groups, monocentric study. The primary objective is to evaluate the effect of naproxcinod on the renal function when co-administered with furosemide in comparison to naproxen and placebo.

Conditions

Renal Hemodynamics

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: QUADRUPLE

Study Groups

naproxen

Group Type: ACTIVE_COMPARATOR

Naproxen

Intervention Type: DRUG

Naproxen 500 mg bid

naproxcinod

Group Type: EXPERIMENTAL

naproxcinod

Intervention Type: DRUG

naproxcinod 750 mg bid

furosemide

Intervention Type: DRUG

furosemide

placebo

Group Type: PLACEBO_COMPARATOR

placebo

Intervention Type: DRUG

placebo

Interventions

naproxcinod

naproxcinod 750 mg bid

Intervention Type: DRUG

Naproxen

Naproxen 500 mg bid

Intervention Type: DRUG

placebo

placebo

Intervention Type: DRUG

furosemide

furosemide

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Healthy, non smoker male subjects aged 18 and 35 years (inclusive), at the Screening visit.

2. Body Mass Index (BMI) strictly between 18 and 30 kg/m² (inclusive) with body weight≥ 50 kg at the Screening visit.

3. Normal physical examination at the Screening visit.

4. Normal ECG (12-lead) at the Screening visit, as judged by the Investigator.

5. At Screening and run-in period visits , Systolic Blood Pressure (SBP) between 100 and 139 mmHg (inclusive) and Diastolic Blood Pressure (DBP) between 50 and 89 mmHg (inclusive).

6. At Screening and run-in period visits, HR between 45 and 90 bpm (inclusive).

7. Subjects must be able to understand the written information sheet and informed consent and comply with all study requirements.

8. Subjects must provide a written, dated and signed informed consent prior to any study procedure.

Exclusion Criteria

1. A history of hypersensitivity reactions (such as asthma, rhinitis, or urticaria) to aspirin, naproxen or any other NSAIDs; or hypersensitivity or contraindications to organic nitrate drugs or hypersensitivity to furosemide or to sinistrine or PAH.

2. Family history of hypertension which may disqualify the subject, as judged by the investigator..

3. History of any clinically relevant gastrointestinal (such as gastritis or gastric ulcer), respiratory, psychiatric, neurologic, kidney, liver, cardiac disease, bleeding disorder, other disease/condition or abnormal physical finding which may interfere with the study objectives. The investigator may disqualify any subject for a sound medical or psychiatric reason.

4. History or presence of ASAT >40UI/L, ALAT >40UI/L, serum bilirubin 3 times above the Upper Limit of Normal range at the Screening visit.

5. Creatinine clearance inferior/equal to 80 ml/min as calculated with the Cockcroft-Gault formula (Appendix 5 of the protocol) at the Screening visit.

6. Plasmatic potassium <3.5 mmole/L at the Screening visit.

7. Seropositivity for HBs, HBc, HIV 1 or HIV 2 at the Screening visit.

8. Donations of blood, plasma or platelets within 3 months prior to the Screening visit or donation planned during the 3 months following Day 8.

9. Any clinically significant abnormal laboratory values at the Screening visit.

10. At the Screening visit, after 1 minute in a standing position, a drop of more than 20 mmHg in SBP or 10 mmHg in DBP or a clinical manifestation of postural hypotension.

11. Chronic use of any drugs (prescription or OTC) within 4 weeks prior to Visit 2 (single use of medication such as paracetamol for headache will be tolerated at the lowest possible dose).

12. Intake of any Nitric Oxide Synthase Inhibitor within 1 month before Screening visit.

13. History of drug addiction or alcohol abuse as defined by DSM IVR, diagnostic criteria for drug and alcohol abuse or drug addiction.

14. Positive drug screening (opiates, cannabinoids, cocaine, benzodiazepines, amphetamines, barbiturates) at the Screening visit.

15. Current participation or participation within 60 days prior to the Screening visit, in another investigational study, including the present study or any previous enrolment in a naproxcinod study.

16. In custody due to an administrative or a legal decision, or under tutelage, or being admitted to a sanitary or social institution.

17. Any direct or indirect involvement with the study conduct or staff at site or any family link with study site staff.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

NicOx

INDUSTRY

Sponsor Role: lead

Responsible Party

NicOx

Other Identifiers

HCT3012-X-113

Identifier Type: -

Identifier Source: org_study_id