Study of the Effect of Inhaled Anesthetics on Diastolic Heart Function Using a Doppler-derived Efficiency Index

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

21 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-11-30

Study Completion Date

2010-10-31

Brief Summary

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The purpose of this study is to determine the effect of inhaled anesthetic drugs upon diastolic heart function (heart suction and filling performance) in patients who are undergoing coronary bypass surgery.

Detailed Description

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Diastolic heart dysfunction is a significant cause of cardiovascular morbidity and is the cause of symptomatic heart failure in approximately one half of patients who are admitted to hospitals with heart failure symptoms. However, diastolic heart function remains difficult to measure objectively without cardiac catheterization. Diastolic heart dysfunction is also common among patients undergoing coronary bypass grafting (CABG) surgery. Despite the ubiquitous use of inhaled volatile drugs to maintain anesthesia in these patients, their effects upon diastolic heart function remain unclear.

Conditions

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Diastolic Dysfunction Coronary Artery Disease General Anesthesia

Keywords

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Diastole, physiopathology coronary artery disease volatile anesthetic sevoflurane

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Non-emergent coronary bypass grafting surgery
* Left ventricular ejection fraction of 40% or greater

Exclusion Criteria

* Myocardial infarction within 4 weeks
* Greater than mild cardiac valvular pathology
* Body mass index greater than 35
* Cardiac dysrhythmias or pacemaker therapy
* Left bundle branch block
* Uncontrolled gastroesophageal reflux disease

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Washington University School of Medicine, Department of Anesthesiology

Principal Investigators

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Troy S Wildes, MD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine, Department of Anesthesiology

Locations

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Barnes-Jewish Hospital

St Louis, Missouri, United States

Site Status

Countries

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United States

References

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Shmuylovich L, Kovacs SJ. Load-independent index of diastolic filling: model-based derivation with in vivo validation in control and diastolic dysfunction subjects. J Appl Physiol (1985). 2006 Jul;101(1):92-101. doi: 10.1152/japplphysiol.01305.2005. Epub 2006 Mar 30.

Reference Type BACKGROUND

PMID: 16575023 (View on PubMed)

Boskovski MT, Shmuylovich L, Kovacs SJ. Transmitral flow velocity-contour variation after premature ventricular contractions: a novel test of the load-independent index of diastolic filling. Ultrasound Med Biol. 2008 Dec;34(12):1901-8. doi: 10.1016/j.ultrasmedbio.2008.05.002. Epub 2008 Aug 9.