Cardiac Autonomic Neuropathy in Patients With Metabolic Syndrome

NCT ID: NCT00907127

Last Updated: 2013-12-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-01-31
• Study Completion Date: 2011-12-31

Brief Summary

The study will test whether damage of the heart nerves appears in patients before they develop diabetes.

Detailed Description

Patients who have mild abnormalities of blood sugar, high blood pressure, abnormal lipids and/or obesity can have a condition called metabolic syndrome. These patients are at high risk for diabetes and Cardiac Autonomic Neuropathy (CAN). Subjects with diagnosed metabolic syndrome will be expected to participate in the Metabolic Fitness Program which is a University of Michigan diet exercise program located in the Cardiology department at Domino Farms in Ann Arbor. Time required for this program and the study is 6 months. Clinic visits will involve Cardiac autonomic testing (CAN) procedures, PET scans and labs which will measure pre and post program intervention.

Conditions

Metabolic Syndrome

Keywords

Metabolic; Syndrome; CAN

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Mediterranean Diet and Exercise

Mediterranean Diet and Exercise

Group Type: ACTIVE_COMPARATOR

Exercise and Diet (Metabolic Fitness Program)

Intervention Type: BEHAVIORAL

6 month program of diet and exercise training and support.

Interventions

Exercise and Diet (Metabolic Fitness Program)

6 month program of diet and exercise training and support.

Intervention Type: BEHAVIORAL

Other Intervention Names

Metabolic Fitness Program

Eligibility Criteria

Inclusion Criteria

1. Subjects must have IGT or IFG and two other criteria of metabolic syndrome as defined by ATP III (IFG=fasting glucose ≥ 100 mg/dl (5.5 mmol/l))

2. Definition of IGT/IFG: IGT/IFG will be defined based on the ADA diagnostic guidelines following an oral glucose tolerance test (OGTT) [2].

3. Other Required Criteria (2 of the following):

• Waist circumference ≥ 102 cm (40 inches) in men and ≥ 88 cm (35 inches) in women, {for Asian-Americans: men ≥ 88 cm (35 inches), women ≥ 78 cm (31 inches)}
• Triglycerides ≥ 150 mg/dl (1.7 mmol/l) - patients on drug treatment with fibrates or nicotinic acid will be presumed to have triglycerides ≥ 150mg/dl and low HDL
• HDL cholesterol < 40 mg/dl (1.0 mmol/l) in men and < 50 mg/dl (1.3 mmol/l) in women,
• Blood pressure ≥ 130/≥ 85 mmHg

4. Age 18-65

5. Women of childbearing potential must be using contraception to prevent pregnancy

Exclusion Criteria

1. Patients either pregnant or planning to become pregnant will be excluded

• Women of childbearing potential will have a urine pregnancy test as part of the screening visit
• Subjects who become pregnant during the study will undergo an exit visit and management of their IGT and Metabolic Syndrome will be returned to their primary care provider

2. Subjects with pre-existing cardiovascular disease including:

• myocardial infarction
• congestive heart failure
• known arrhythmias
• ventricular structural abnormalities and valvular disease
• peripheral vascular disease

3. Subjects with hypoxemic lung or heart disease

4. Subjects with established diabetes

5. Laboratory evidence for a disease known to cause neuropathy within 3 months of screening will be an exclusion (those without known abnormality or those with a remote abnormality (> 3 months) will undergo the serologic screening)

6. Significant neurological disease (e.g., Parkinson's disease, epilepsy, recent stroke)

7. Subjects taking drugs which interfere with the uptake or metabolism of catecholamines

8. Subjects with known history of chronic kidney disease or who have significant hepatic disease (AST, ALT > 3 times upper limit for normal) or a history of previous kidney, pancreas or cardiac transplantation.

9. Subjects having taken systemic investigational drugs within the last 6 months

10. Inability or unwillingness of subject or legal guardian/representative to give written informed consent

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

American Diabetes Association

OTHER

Sponsor Role: collaborator

University of Michigan

OTHER

Sponsor Role: lead

Responsible Party

Rodica Pop-Busui

Associate Professor of Internal Medicine/MEND

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Rodica Pop-Busui, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

The University of Michigan Health System

Ann Arbor, Michigan, United States

Countries

United States

References

Mathew AV, Li L, Byun J, Guo Y, Michailidis G, Jaiswal M, Chen YE, Pop-Busui R, Pennathur S. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care. 2018 Nov;41(11):2431-2437. doi: 10.2337/dc18-0049. Epub 2018 Sep 10.

Reference Type: DERIVED

PMID: 30201848 (View on PubMed)

Other Identifiers

ADA

Identifier Type: -

Identifier Source: secondary_id

UM-5428

Identifier Type: -

Identifier Source: org_study_id