Tarceva And Radiotherapy in Locally Advanced Lung Cancer Non-small Cell Lung Cancer

NCT ID: NCT00888511

Last Updated: 2020-11-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-05-31

Study Completion Date

2016-05-31

Brief Summary

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The trial is a phase II study of daily Tarceva combined with definitive radiotherapy in inoperable locally advanced non small cell lung cancer (stage IIB-IIIB). The objective of the phase II trial is to examine Tarceva concomitant with curatively intended irradiation 66 Gy (2 Gy x 33 F, 5 F per week).

Detailed Description

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Conditions

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Non-small Cell Lung Cancer

Keywords

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Lung cancer Non-small cell lung cancer Tarceva Radiotherapy Local-regionally advanced non-small cell lung cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Tarceva

Intervention Type DRUG

Tarceva 150 mg/day

Radiotherapy

Intervention Type RADIATION

66 Gy/33 F/5 F per week for 5 weeks

Interventions

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Tarceva

Tarceva 150 mg/day

Intervention Type DRUG

Radiotherapy

66 Gy/33 F/5 F per week for 5 weeks

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years
* Patients with histologically or cytologically documented diagnosis locally advanced NSCLC stage IIB to IIIB without pleural effusion
* Performance status ≤2 on the ECOG scale
* Serum bilirubin must be ≤1.5 upper limit of normal (ULN)
* ALAT ≤2 x ULN
* Able to comply with study and follow-up procedures
* Patients with reproductive potential must use effective contraception
* Written (signed) informed consent to participate in the study

Exclusion Criteria

* Any unstable systemic disease (including active infection, unstable angina, congestive heart failure, severe hepatic, renal, or metabolic disease)
* Any other malignancies within 5 years (except for adequately treated carcinoma in situ of the cervix or basal or squamous cell skin cancer)
* Inability to take oral medication, or requirement of intravenous alimentation
* Nursing mothers
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Odense University Hospital

OTHER

Sponsor Role collaborator

Copenhagen University Hospital at Herlev

OTHER

Sponsor Role collaborator

Rigshospitalet, Denmark

OTHER

Sponsor Role collaborator

Aalborg University Hospital

OTHER

Sponsor Role collaborator

Aarhus University Hospital

OTHER

Sponsor Role collaborator

Naestved Hospital

OTHER

Sponsor Role collaborator

Olfred Hansen

OTHER

Sponsor Role lead

Responsible Party

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Olfred Hansen

MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Olfred Hansen, MD

Role: PRINCIPAL_INVESTIGATOR

Odense University Hospital

Locations

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Department of Oncology, Aarhus University Hospital

Aarhus, , Denmark

Site Status

Department of Oncology, Rigshospitalet

Copenhagen, , Denmark

Site Status

Department of Oncology, Copenhagen University Hospital at Herlev

Herlev, , Denmark

Site Status

Department of Oncology, Naestved Hospital

Næstved, , Denmark

Site Status

Laboratory of Radiation Physics

Odense, , Denmark

Site Status

Odense University Hospital

Odense, , Denmark

Site Status

Department of Oncology, Vejle Hospital

Vejle, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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09.02

Identifier Type: -

Identifier Source: org_study_id