XIAP Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)

NCT ID: NCT00882869

Last Updated: 2011-07-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 75 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-03-31
• Study Completion Date: 2011-05-31

Brief Summary

AEG35156 is a second generation antisense which targets XIAP mRNA to lower XIAP levels and the apoptotic threshold of cancer cells, enhancing their sensitivity to intrinsic death and chemotherapy. Advanced HCC is an attractive target for AEG35156 since XIAP is highly expressed in HCC and may prevent cancer cells from undergoing apoptosis. Second generation antisense molecules are known to accumulate in liver where AEG35156 may down regulate XIAP protein expression in HCC cells thus promoting their apoptotic death.

Conditions

Advanced Hepatocellular Carcinoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

AEG35156 antisense IV infusion

Dose escalation (100, 200 and 300 mg/day) over 2 hr infusion, once weekly over 21 days (Day 1, 8, 15)

Intervention Type: DRUG

Sorafenib

Sorafenib will be administered at 400 mg BID every day

Intervention Type: DRUG

Other Intervention Names

nexavar

Eligibility Criteria

Inclusion Criteria

• HCC diagnosed by:

• Histology, or
• AASLD Criteria in which the diagnosis is made clinically in a patient with a known hepatitis B or cirrhosis of other etiology has a liver mass of > 2cm with typical features of HCC (i.e., hypervascular with washout in the portal/venous phase) on a dynamic imaging study (contrast CT / USG / MRI) or alternatively if the AFP is >200 ng/ml.
• The tumor is not suitable for curative treatment (resection / transplant / local ablative therapies) or the patient is medically inoperable or refuses such treatment.
• At least one measurable lesion according to RECIST criteria.
• Age > 18 years.
• Life expectancy of greater than 12 weeks.
• ECOG performance status ≤ 2 (please refer to Appendix 1).
• Child-Pugh score A or B (please refer to Appendix 2).
• Adequate organ functions defined as:

• ANC ≥ 1.5 x 109/L
• Platelet count ≥ 75 x 109/L
• Creatinine ≤ 1.5 x ULN
• ALT or AST < 2.5 x ULN
• Total bilirubin < 50 μmol/L
• INR <1.7
• No encephalopathy clinically
• Normal ECG
• For women of child-producing potential, the use of effective contraceptive methods during the study.
• Prior local therapy to tumor (e.g. surgery, RFA, PEI, chemo-embolization, radiotherapy) is allowed provided that there is a target lesion not subjected to local therapy and/or disease progression has been documented in the target lesion subjected to local therapy. The treatment must be completed at least 4 weeks and patient has recovered from all the acute toxicities of that treatment.
• For patients with hepatitis B, the patient must receive antiviral therapy prior to or with registration.

Exclusion Criteria

• Child-Pugh score C.
• Patients who have had prior systemic chemotherapy.
• Patients who have had any other cancer related therapy including radiotherapy within 4 weeks prior to entering the study.
• Patients receiving any other investigational agents concurrently.
• Patients with known brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
• Patients who have peripheral neuropathy.
• Uncontrolled intercurrent disease such as, but not limited to, ongoing or active infection or psychiatric illness/social situations that would limit compliance with study requirements.
• Known bleeding diathesis.
• Pregnant or nursing women. NOTE: Women of child-bearing potential must agree to use adequate contraception (sterile or surgically sterile; hormonal or barrier method of birth control; or abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
• Men who are unwilling to use acceptable forms of birth control when engaging in sexual contact with women of child bearing potential.
• Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy.
• Serious nonmalignant disease that could compromise protocol objectives in the opinion of the investigator and/or the sponsor.
• Patients who are currently receiving any other investigational agent. Subjects who have used a previous antisense oligonucleotide in the last 90 days will be excluded.
• Unwillingness or inability to comply with procedures required in this protocol.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chinese University of Hong Kong

OTHER

Sponsor Role: collaborator

Aegera Therapeutics

INDUSTRY

Sponsor Role: lead

Responsible Party

Aegera Therapeutics Inc

Principal Investigators

Ann Shing Lee, MBChB(CUHK), FHKAM(Rad)

Role: PRINCIPAL_INVESTIGATOR

Tuen Mun Hospital

Locations

Tuen Mun Hospital

Tuenmen, New Territories, Hong Kong, China

Queen Elizabeth Hospital

Hong Kong, , China

Queen Mary Hospital

Hong Kong, , China

Countries

China

References

Lee FA, Zee BC, Cheung FY, Kwong P, Chiang CL, Leung KC, Siu SW, Lee C, Lai M, Kwok C, Chong M, Jolivet J, Tung S. Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC). Am J Clin Oncol. 2016 Dec;39(6):609-613. doi: 10.1097/COC.0000000000000099.

Reference Type: DERIVED

PMID: 24977690 (View on PubMed)

Other Identifiers

AEG35156-205

Identifier Type: -

Identifier Source: org_study_id