A Study To Assess The Effect Of PF-03526299 On Lung Function Following An Allergen Challenge In Asthmatic Subjects

NCT ID: NCT00877539

Last Updated: 2010-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

29 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-30

Study Completion Date

2010-07-31

Brief Summary

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PF-03526299, a novel anti-inflammatory agent should attenuate the effect of a bronchial allergen challenge on lung function and hence provide proof of mechanism for this agent.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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PF-03526299

Group Type EXPERIMENTAL

PF-03526299

Intervention Type DRUG

Inhaled, two doses 4 hours apart

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Inhaled, two doses 4 hours apart

Fluticasone propionate

Group Type ACTIVE_COMPARATOR

Fluticasone propionate

Intervention Type DRUG

Inhaled

Interventions

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PF-03526299

Inhaled, two doses 4 hours apart

Intervention Type DRUG

Placebo

Inhaled, two doses 4 hours apart

Intervention Type DRUG

Fluticasone propionate

Inhaled

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Males and females 18-60 years
* Mild asthma
* Atopic to allergens

Exclusion Criteria

* Unstable asthma
* Smokers or recent ex-smokers
* Recent allergen challenge
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Pfizer, Inc.

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

London, , United Kingdom

Site Status

Pfizer Investigational Site

Manchester, , United Kingdom

Site Status

Countries

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United Kingdom

Related Links

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Other Identifiers

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A9291002

Identifier Type: -

Identifier Source: org_study_id