Effect of Remote Ischemic Preconditioning on Cognitive Function After Cardiac Surgery
NCT ID: NCT00877305
Last Updated: 2012-01-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE1
180 participants
INTERVENTIONAL
2008-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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RIPC
Remote Ischemic Preconditioning
Remote Ischemic Preconditioning
RIPC will be induced during anesthesia by four 5-min cycles of upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to 200 mmHg (at least a pressure 15 mm Hg greater than the systolic arterial pressure measured via the arterial line).
CONTROL
Control
Control
Sham intervention with four 5-min cycles of inflation of the blood pressure cuff at 20 mmHg and 5 min deflation without any upper leg ischaemia.
Interventions
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Remote Ischemic Preconditioning
RIPC will be induced during anesthesia by four 5-min cycles of upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to 200 mmHg (at least a pressure 15 mm Hg greater than the systolic arterial pressure measured via the arterial line).
Control
Sham intervention with four 5-min cycles of inflation of the blood pressure cuff at 20 mmHg and 5 min deflation without any upper leg ischaemia.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Myocardial infarction up to 7 days prior to enrollment
* Stroke up to 2 months prior to enrollment
* Ejection fraction less than 30%
* Previous psychiatric and neurological illness
* Inability to give informed consent
18 Years
ALL
No
Sponsors
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University Hospital Schleswig-Holstein
OTHER
Patrick Meybohm
OTHER
Responsible Party
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Patrick Meybohm
PD Dr.
Principal Investigators
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Patrick Meybohm, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital Schleswig-Holstein
Berthold Bein, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital Schleswig-Holstein
Locations
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University Hospital Schleswig-Holstein
Kiel, , Germany
Countries
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References
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Zitta K, Meybohm P, Bein B, Gruenewald M, Lauer F, Steinfath M, Cremer J, Zacharowski K, Albrecht M. Activities of cardiac tissue matrix metalloproteinases 2 and 9 are reduced by remote ischemic preconditioning in cardiosurgical patients with cardiopulmonary bypass. J Transl Med. 2014 Apr 8;12:94. doi: 10.1186/1479-5876-12-94.
Meybohm P, Renner J, Broch O, Caliebe D, Albrecht M, Cremer J, Haake N, Scholz J, Zacharowski K, Bein B. Postoperative neurocognitive dysfunction in patients undergoing cardiac surgery after remote ischemic preconditioning: a double-blind randomized controlled pilot study. PLoS One. 2013 May 31;8(5):e64743. doi: 10.1371/journal.pone.0064743. Print 2013.
Other Identifiers
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A165/08
Identifier Type: -
Identifier Source: org_study_id
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