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NCT00876811

Effect of Red Raspberry Consumption on Fasting Oxidative Stress Biomarkers

NCT ID: NCT00876811

Last Updated: 2010-10-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-03-31

Study Completion Date

2009-05-31

Brief Summary

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The purpose of this study is determine whether daily consumption of frozen red raspberries can improve the antioxidant capacity of the blood and reduce the effects of oxidative stress, dose-dependently, in a healthy adult population.

Detailed Description

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Red raspberries are an excellent source of numerous polyphenolic antioxidants. The bioactivity of these compounds have been implicated in many biological pathways and may function to reduce the risk of numerous chronic diseases. We are conducting an intervention study with frozen red raspberries on a healthy adult population in order to determine if raspberry polyphenols are bioavailable and bioactive in vivo. Twenty-four subjects (12 male and 12 female) will be recruited to participate and consume one-cup frozen red raspberries daily for two weeks, they then will randomly be assigned to consume either one, two or four cups of raspberries for another two weeks, this will be followed by four weeks of non-treatment. Blood samples and 12-hour urine collections will be taken in order to measure the concentration of raspberry polyphenols in response to treatment dose. Dose-dependent treatment effects on blood biomarkers for antioxidant capacity, oxidative stress, inflammation and other chronic disease risk factors will also be measured.

Conditions

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Oxidative Stress

Keywords

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raspberry fruit antioxidants polyphenols oxidative stress dietary intervention

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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one-cup

Group Type EXPERIMENTAL

individually quick frozen red raspberries

Intervention Type DIETARY_SUPPLEMENT

Consumption of one-cup frozen red raspberries daily for four weeks, followed by a four week period of non-treatment.

two-cups

Group Type EXPERIMENTAL

individually quick frozen red raspberries

Intervention Type DIETARY_SUPPLEMENT

Consumption of one-cup frozen red raspberries for two weeks, then consumption of two-cups frozen red raspberries for an additional two weeks, followed by four weeks of non-treatment.

four-cups

Group Type EXPERIMENTAL

individually quick frozen red raspberries

Intervention Type DIETARY_SUPPLEMENT

Consumption of one-cup frozen red raspberries for two weeks, then consumption of four-cups frozen red raspberries for an addition two weeks, followed by four weeks of non-treatment.

Interventions

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individually quick frozen red raspberries

Consumption of one-cup frozen red raspberries daily for four weeks, followed by a four week period of non-treatment.

Intervention Type DIETARY_SUPPLEMENT

individually quick frozen red raspberries

Consumption of one-cup frozen red raspberries for two weeks, then consumption of two-cups frozen red raspberries for an additional two weeks, followed by four weeks of non-treatment.

Intervention Type DIETARY_SUPPLEMENT

individually quick frozen red raspberries

Consumption of one-cup frozen red raspberries for two weeks, then consumption of four-cups frozen red raspberries for an addition two weeks, followed by four weeks of non-treatment.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* healthy adults

Exclusion Criteria

* obese (\>30kg/m2)
* high blood pressure (140/90mmHg)
* allergic to raspberries
* pregnant or lactating
* history of chronic disease
* currently taking medication

Minimum Eligible Age

18 Years

Maximum Eligible Age

43 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Unity Health Toronto

OTHER

Sponsor Role collaborator

University of Toronto

OTHER

Sponsor Role lead

Responsible Party

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Department of Nutritional Sciences, Faculty of Medicine, University of Toronto

Principal Investigators

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A V Rao, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Nutritional Sciences, University of Toronto

Locations

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Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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22069

Identifier Type: -

Identifier Source: org_study_id