In Vitro Maturation With in Vitro Fertilization (IVF) Compared to Mild in Vitro Fertilization

NCT ID: NCT00867763

Last Updated: 2010-08-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

NA

Total Enrollment

1440 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-03-31

Study Completion Date

2012-06-30

Brief Summary

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Methods of infertility treatment may involve in vitro fertilization or IVF. Though effective, IVF is complex and expensive. Methods using no gonadotropin hormone stimulation of the ovaries are being compared to mild stimulation doses. The goal of the research is to determine which of these if more suitable as a low cost approach for varying individual patients.

Detailed Description

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Low cost environment is utilized, but fees are charged.

Conditions

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Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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IVM

Early egg retrieval, in vitro maturation, then IVF

Group Type EXPERIMENTAL

In vitro maturation and in vitro fertilization

Intervention Type PROCEDURE

No gonadotropin, eggs harvested early

Mild IVF

Mild gonadotropin and conventional IVF

Group Type ACTIVE_COMPARATOR

Low doses of gonadotropin stimulation.

Intervention Type PROCEDURE

Gonadotropin followed by conventional IVF

Interventions

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In vitro maturation and in vitro fertilization

No gonadotropin, eggs harvested early

Intervention Type PROCEDURE

Low doses of gonadotropin stimulation.

Gonadotropin followed by conventional IVF

Intervention Type PROCEDURE

Other Intervention Names

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assisted reproduction Assisted reproduction, IVF.

Eligibility Criteria

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Inclusion Criteria

* Under age 42 female, normal uterine cavity, BMI 18-34kg/m2,

Exclusion Criteria

* Donor eggs, donor sperm, myoma over 5 cm
* Current hydrosalpinx, abnormal uterine cavity.
Minimum Eligible Age

21 Years

Maximum Eligible Age

41 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Batzofin Fertility Services

OTHER

Sponsor Role lead

Responsible Party

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Massey

Principal Investigators

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Joe B Massey, MD

Role: PRINCIPAL_INVESTIGATOR

Batzofin Fertility Services

Locations

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Batzofin Fertilty Services

New York, New York, United States

Site Status

BFS

New York, New York, United States

Site Status

Countries

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United States

References

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Son WY, Chung JT, Herrero B, Dean N, Demirtas E, Holzer H, Elizur S, Chian RC, Tan SL. Selection of the optimal day for oocyte retrieval based on the diameter of the dominant follicle in hCG-primed in vitro maturation cycles. Hum Reprod. 2008 Dec;23(12):2680-5. doi: 10.1093/humrep/den332. Epub 2008 Sep 4.

Reference Type BACKGROUND
PMID: 18775885 (View on PubMed)

Son WY, Chung JT, Demirtas E, Holzer H, Sylvestre C, Buckett W, Chian RC, Tan SL. Comparison of in-vitro maturation cycles with and without in-vivo matured oocytes retrieved. Reprod Biomed Online. 2008 Jul;17(1):59-67. doi: 10.1016/s1472-6483(10)60294-5.

Reference Type BACKGROUND
PMID: 18616892 (View on PubMed)

Other Identifiers

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2939

Identifier Type: -

Identifier Source: org_study_id

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