Sitagliptin Umbilical Cord Blood Transplant Study

NCT ID: NCT00862719

Last Updated: 2016-10-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 29 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-03-31
• Study Completion Date: 2015-02-28

Brief Summary

The main purpose of this trial is to study whether the drug sitagliptin can be given safely to patients undergoing umbilical cord blood transplantation to speed up engraftment (recovery of blood counts after transplant).

Detailed Description

Umbilical cord blood (UCB) is increasingly used as a source of stem cells for patients with blood cancers who need an allogeneic stem cell transplant (a transplant with stem cells from another person) but who have no suitably matched donors. The advantages of UCB are that (1) it is associated with less risk of transmitting an infection from a donor, (2) it can be more safely given even if not completely matched compared to bone marrow or blood stem cells, and (3) it is much more quickly available than unrelated donor bone marrow or blood stem cells. While more commonly used for transplantation in children, UCB is increasingly being used in adults. However, because they are larger than children, the relatively smaller stem cell dose in UCB is major limitation for transplantation in adults, and engraftment can be delayed. This study is investigating whether the drug sitagliptin can be used to increase and speed up engraftment in adults receiving UCB transplantation, overcoming the limitation of small stem cell doses associated with umbilical cord blood.

Sitagliptin is a drug given in tablet form that has been recently approved by the Food and Drug Administration (FDA) for the treatment of certain patients with diabetes mellitus (a disease that results in high blood sugar). Sitagliptin has been given to both normal healthy volunteers and diabetic patients and has been found to be safe and well-tolerated. The drug improves control of blood sugar in diabetics by inhibiting an enzyme called "CD26/DPP-IV." Recent studies at Indiana University (and other centers) have shown that this same enzyme plays an important role in the way transplanted stem cells find their way to the bone marrow and engraft. Transplant studies in mice have found that inhibiting CD26/DPP-IV significantly increases the engraftment of stem cells. Based on these studies, it is believed that drugs that inhibit CD26/DPP-IV, such as sitagliptin, may also increase engraftment in patients who receive clinical stem cell transplants.

Conditions

Leukemia, Myeloid, Acute; Acute Lymphoblastic Leukemia; Myelodysplasia; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Sitagliptin once per day

600 mg sitagliptin once per day orally starting on Day -1 for a total of 4 doses

Group Type: EXPERIMENTAL

Sitagliptin

Intervention Type: DRUG

600 mg sitagliptin taken orally per the schedule listed in each of the three separate arms.

Sitagliptin twice per day

600 mg sitagliptin twice per day orally starting on Day -1 for a total of 8 doses

Group Type: EXPERIMENTAL

Sitagliptin

Intervention Type: DRUG

600 mg sitagliptin taken orally per the schedule listed in each of the three separate arms.

Sitagliptin three times per day

600 mg sitagliptin three times per day orally starting on Day -1 for a total of 12 doses

Group Type: EXPERIMENTAL

Sitagliptin

Intervention Type: DRUG

600 mg sitagliptin taken orally per the schedule listed in each of the three separate arms.

Interventions

Sitagliptin

600 mg sitagliptin taken orally per the schedule listed in each of the three separate arms.

Intervention Type: DRUG

Other Intervention Names

Januvia

Eligibility Criteria

Inclusion Criteria

• Patients must have one of the following disease types with disease-specific features as outlined in the protocol:

• Acute myeloid leukemia (AML)
• Acute lymphoblastic leukemia (ALL)
• Myelodysplasia
• Chronic myelogenous leukemia
• Patients with aggressive non-Hodgkin's lymphoma (NHL), including diffuse large cell lymphoma, mediastinal B-cell lymphoma, transformed lymphoma, mantle cell lymphoma, and peripheral T cell lymphoma
• Hodgkin's lymphoma
• Relapsed Multiple Myeloma
• At least 35 days following start of preceding leukemia induction cytotoxic chemotherapy
• Patient age 18-55 years
• Karnofsky Performance status ≥ 70%
• No availability of a consenting HLA-matched related donor who is either matched fully matched or mismatched at only one locus of HLA-A, -B, and DRB1.
• No availability of a readily available HLA-matched volunteer unrelated donor (8 of 8 allele match at HLA-A, -B, -C and -DRB1). Patients with unstable disease who are in danger of significant disease progression while waiting to procure volunteer donor cells will be eligible to be treated on this protocol, even if a matched donor is available.
• Patients must have a matched or partially matched UCB unit with greater than 1.8 x10-7 nucleated cells/kg of recipient weight at the time of cryopreservation.
• No current uncontrolled bacterial, viral or fungal infection (defined as currently taking medication and progression of clinical symptoms).
• No HIV disease. Patients with immune dysfunction are at a significantly higher risk of infection from intensive immunosuppressive therapies.
• Non pregnant and non-nursing. Treatment under this protocol would expose a fetus to significant risks.
• Required baseline laboratory values as defined in the protocol

Exclusion Criteria

• Symptomatic uncontrolled coronary artery disease or congestive heart failure.
• Severe hypoxemia with room air PaO2 less than 70, supplemental oxygen dependence, or DLCO less than 50 percent predicted
• Patients with central nervous system (CNS) involvement refractory to intrathecal chemotherapy
• Prior allogeneic or autologous hematopoietic stem cell transplant in the last 6 months

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 59 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Indiana University School of Medicine

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Sherif Farag, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

IU Simon Cancer Center

Locations

IU Simon Cancer Center

Indianapolis, Indiana, United States

Countries

United States

References

Farag SS, Srivastava S, Messina-Graham S, Schwartz J, Robertson MJ, Abonour R, Cornetta K, Wood L, Secrest A, Strother RM, Jones DR, Broxmeyer HE. In vivo DPP-4 inhibition to enhance engraftment of single-unit cord blood transplants in adults with hematological malignancies. Stem Cells Dev. 2013 Apr 1;22(7):1007-15. doi: 10.1089/scd.2012.0636. Epub 2013 Feb 15.

Reference Type: DERIVED

PMID: 23270493 (View on PubMed)

Other Identifiers

0812-15; IUCRO-0223

Identifier Type: -

Identifier Source: org_study_id