Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection
NCT ID: NCT00859677
Last Updated: 2023-02-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
52 participants
OBSERVATIONAL
2009-03-31
2016-08-26
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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1
HIV-positive and MRSA negative
No interventions assigned to this group
2
HIV-positive and MRSA infected (skin/soft tissue)
No interventions assigned to this group
3
HIV-positive and MRSA colonized
No interventions assigned to this group
4
HIV-negative and MRSA negative
No interventions assigned to this group
5
HIV-negative and MRSA infected (skin/soft tissue)
No interventions assigned to this group
6
HIV-negative and MRSA colonized
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Willingness to undergo blood draw. Skin biopsy will be requested, but is optional
-AND-
HIV-positive and MRSA-negative Group:
* Documented positive HIV test result
* Negative colonization swabs for S. aureus within 14 days of enrollment
* No evidence of skin/soft tissue infection
HIV-positive and MRSA-Colonization Group:
* Documented positive HIV test result
* History of of colonization with MRSA w/in 14 days of study enrollment
HIV-positive and MRSA Infection Group:
* Documented positive HIV test result
* Skin/soft tissue infection with a positive wound culture showing MRSA within 7 days of enrollment
* MRSA infection is not associated with an intravenous catheter or other nosocomial procedure
HIV Negative groups:
* Same criteria used for the HIV-negative groups as listed above.
* No history of HIV infection.
* Willing to undergo an HIV blood test, which must have a negative result.
Exclusion Criteria
* Women who are within 6 months of being postpartum or who are currently breastfeeding
* Subjects unable or unwilling to complete questionnaires and blood draw.
18 Years
ALL
Yes
Sponsors
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Infectious Diseases Clinical Research Program
OTHER
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Henry M. Jackson Foundation for the Advancement of Military Medicine
OTHER
Responsible Party
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Locations
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Naval Medical Center San Diego
San Diego, California, United States
Walter Reed National Military Medical Center
Bethesda, Maryland, United States
Countries
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References
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Utay NS, Roque A, Timmer JK, Morcock DR, DeLeage C, Somasunderam A, Weintrob AC, Agan BK, Estes JD, Crum-Cianflone NF, Douek DC. MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity. PLoS Pathog. 2016 Apr 19;12(4):e1005580. doi: 10.1371/journal.ppat.1005580. eCollection 2016 Apr.
Other Identifiers
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IDCRP -023
Identifier Type: -
Identifier Source: org_study_id
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