Effects of Arabinoxylan-Oligosaccharides Compared to Other Prebiotics in Healthy Subjects

NCT ID: NCT00853034

Last Updated: 2009-02-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2007-09-30

Brief Summary

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The purpose of the study is to evaluate the effects of arabinoxylan-oligosaccharides (AXOS) on the colonic metabolism and microbial composition, and to compare these effects with the reference prebiotic fructo-oligosaccharide enriched inulin.

Detailed Description

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Conditions

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Healthy

Keywords

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gastrointestinal effects prebiotic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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FOS-IN

prebiotic fructo-oligosaccharide enriched inulin

Group Type ACTIVE_COMPARATOR

FOS-IN

Intervention Type DIETARY_SUPPLEMENT

prebiotic fructo-oligosaccharide enriched inulin

intake period: 2 weeks, 1.25 or 2.50g every morning and evening

AXOS

arabinoxylan-oligosaccharides (AXOS)

Group Type EXPERIMENTAL

AXOS

Intervention Type DIETARY_SUPPLEMENT

arabinoxylan-oligosaccharides (AXOS)

intake period: 2 weeks, 1.25 or 2.50g every morning and evening

Interventions

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FOS-IN

prebiotic fructo-oligosaccharide enriched inulin

intake period: 2 weeks, 1.25 or 2.50g every morning and evening

Intervention Type DIETARY_SUPPLEMENT

AXOS

arabinoxylan-oligosaccharides (AXOS)

intake period: 2 weeks, 1.25 or 2.50g every morning and evening

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Synergy1, Orafti, Tienen

Eligibility Criteria

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Inclusion Criteria

* healthy
* 18-45 years
* regular eating pattern

Exclusion Criteria

* gastrointestinal complaints
* antibiotic intake
* medication influencing gut transit or microbiota
* abdominal surgery
* pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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KU Leuven

OTHER

Sponsor Role lead

Principal Investigators

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Kristin Verbeke, PhD

Role: STUDY_DIRECTOR

KU Leuven

Locations

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Department of Gastrointestinal Research, Laboratory Digestion and Absorption

Leuven, Leuven, Belgium

Site Status

Countries

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Belgium

References

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Cloetens L, De Preter V, Swennen K, Broekaert WF, Courtin CM, Delcour JA, Rutgeerts P, Verbeke K. Dose-response effect of arabinoxylooligosaccharides on gastrointestinal motility and on colonic bacterial metabolism in healthy volunteers. J Am Coll Nutr. 2008 Aug;27(4):512-8. doi: 10.1080/07315724.2008.10719733.

Reference Type BACKGROUND
PMID: 18978172 (View on PubMed)

Other Identifiers

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AXOS 001

Identifier Type: -

Identifier Source: org_study_id