Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
52 participants
OBSERVATIONAL
2008-02-29
2009-12-31
Brief Summary
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Detailed Description
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In line with the National Institute on Drug Abuse's (NIDA) emphasis on novel methods for investigating substance use disorders, the current study proposes to use fMRI to better understand the neurological correlates of cue reactivity among nicotine dependent smokers. This approach will permit the isolation of pathways that are relevant to cue induced craving.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Non-smoker
Non-smoking control
No interventions assigned to this group
Nicotine Dependent Smoking Group
current smokers
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Participants will meet criteria for primary nicotine dependence, smoke at least 70% of days in the last 30 days prior to assessment.
3. Able to read and understand questionnaires and informed consent.
4. Right-handed.
5. Currently is not engaged in, and does not want, treatment for nicotine related problems.
6. Able to maintain abstinence from nicotine during the study period.
7. Participants must have a negative rapid-screening UDS and pregnancy test prior to imaging session.
1. Age 18 - 60.
2. Does not meet the DSM-IV criterion for lifetime or current substance dependence.
3. Has used tobacco products no more than on experimental basis (none in past year).
4. Participants must have a negative rapid-screening UDS and pregnancy test prior to session.
5. Righthanded.
Exclusion Criteria
2. Any psychoactive substance abuse within the last 30 days as evidenced by subject report or urine drug screen.
3. Meets DSM-IV criteria for current axis I disorders of major depression, panic disorder, obsessive compulsive disorder, post-traumatic stress syndrome, bipolar affective disorder, schizophrenia, or any other psychotic disorder or organic mental disorder. The rationale for excluding them is that symptoms from these disorders may affect dependent variables and complicate interpretation of the data.
4. Has current suicidal ideation with plan or homicidal ideation.
5. Need for maintenance or acute treatment with any psychoactive medication including antiseizure medications.
6. Clinically significant medical problems such as cardiovascular, renal, GI, or endocrine problem that would impair participation or limit ability to participate in scan.
7. Sexually active females of child-bearing potential who are pregnant (by urine HCG), nursing, or who are not using a reliable form of birth control.
8. Has current charges pending for a violent crime (not including DUI related offenses).
9. Persons with ferrous metal implants or pacemaker since fMRI will be used.
18 Years
60 Years
ALL
Yes
Sponsors
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Medical University of South Carolina
OTHER
Responsible Party
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Medical University of South Carolina - Clinical Neuroscience Division
Principal Investigators
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Karen Hartwell, MD
Role: PRINCIPAL_INVESTIGATOR
Medical Universtiy of South Carolina
Locations
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Medical University of South Carolina
Charleston, South Carolina, United States
Countries
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Other Identifiers
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BOLD fMRI
Identifier Type: -
Identifier Source: org_study_id