The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-06-30

Study Completion Date

2010-09-30

Brief Summary

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Like most endocrine axes, the entero-insular axis is expected to go through an age-related physiological deterioration, what might contribute to special features of the elderly onset type 2 diabetes in comparison to middle-age.

Twenty four NGT volunteers will be evaluated by a meal tolerance test (MTT) for incretin hormone measurements, and by the hyperglycemic clamp followed by an arginine test for assessing the beta-cell function and the acute insulin response. Others parameters as body composition and basic biochemistry will be also evaluated at Laboratory of Investigation on Metabolism and Diabetes - LIMED / State university of Campinas, Brazil.

The characterization of the glucagon-like peptide-1 (GLP-1) production, dipeptidyl peptidase IV (DPP-IV) activity and/or endocrine pancreas incretin-response at aging, might be an interesting evidence to reinforce an incretin-based therapeutic approach for elderly onset type 2 diabetes.

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Detailed Description

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Conditions

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Diabetes Mellitus, Type 2 Insulin Resistance

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Elderly NGT

Normoglycemic subjects 65-80 years old

No interventions assigned to this group

Middle-age NGT

Middle-age normoglycemic subjects 35 to 50 years old.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Stable weight (\< 5% variation) within the last three months
* Age: 35 to 50 years old for middle-age group, and 65 to 80 years old for elderly group.
* BMI: 20 to 29.9 kg/m2
* Normal glucose tolerance (NGT) for groups Elderly and Middle-age

Exclusion Criteria

* Use of estrogen, progestogen or systemic corticosteroids.
* Hepatic cirrhosis, renal failure or any clinical condition with impaired insulin sensitivity
* Smoking
* Obesity
* Uncontrolled systemic or debilitating diseases

Minimum Eligible Age

35 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes