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Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study

NCT ID: NCT00841425

Last Updated: 2009-02-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

33 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-02-28

Study Completion Date

2010-06-30

Brief Summary

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Previously the investigators have found that adolescent elite swimmers, who have been involved in competitive swimming for only a few years, have not developed respiratory symptoms, signs of airway inflammation or airway hyperresponsiveness exept for a slight increase in airway responsiveness to eucapnic voluntary hyperpnea. In the current study, the investigators will be doing a 3-year follow-up study on the swimmers studied previously.

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Detailed Description

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Even though studies suggest that elite sport can cause AHR and airway inflammation, more studies are needed to elucidate how and when AHR and airway inflammation develop; and there is a lack of follow-up studies. The present study will give us a chance to do a follow-up study to register changes in AHR and airway inflammation in athletes without any significant airway changes at baseline.

Conditions

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Asthma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Swimmers

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age 15-19 years
* Part of the Danish National Swimming Association's talent program for young swimmers at the baseline study
* Informed consent

Exclusion Criteria

* Upper respiratory tract infection in the previous 4 weeks (visits will be postponed)
Minimum Eligible Age

15 Years

Maximum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Bispebjerg Hospital

OTHER

Sponsor Role lead

Responsible Party

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Respiratory and Allergy Research Unit, Bispebjerg Hospital, Copenhagen, Denmark

Principal Investigators

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Lars Pedersen, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Respiratory and Allergy Research Unit, Bispebjerg Hospital

Locations

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Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Bispebjerg Hospital

Copenhagen, , Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Lars Pedersen, MD PhD

Role: CONTACT

[email protected]
(+45) 35 31 30 69

Facility Contacts

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Lars Pedersen, MD PhD

Role: primary

[email protected]
(+45) 35 31 30 69

References

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Pedersen L, Lund TK, Barnes PJ, Kharitonov SA, Backer V. Airway responsiveness and inflammation in adolescent elite swimmers. J Allergy Clin Immunol. 2008 Aug;122(2):322-7, 327.e1. doi: 10.1016/j.jaci.2008.04.041. Epub 2008 Jun 12.

Reference Type BACKGROUND
PMID: 18554704 (View on PubMed)

Other Identifiers

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H-B-2009-012

Identifier Type: -

Identifier Source: org_study_id

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