Is Serum YKL-40 Capable of Predicting Intrauterine Growth Restriction (IUGR) and Preeclampsia?
NCT ID: NCT00836524
Last Updated: 2011-10-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
2000 participants
OBSERVATIONAL
2009-01-31
2012-09-30
Brief Summary
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Methods: women attending screening for downs syndrome is scanned with uterine artery doppler and delivered blood samples at GA 12, 20, 25 and 32 respectively. When pregnancy outcome is registered by medical records blood samples are retrieved and analyzed for serum YKL-40. Serum YKL-40 are correlated to the presence of bilateral notching, preeclampsia and different degrees of intrauterine growth restriction.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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1
Pregnant women are included when they attend nuchal transcluency examination and will during their pregnancy be examined 4 times with ultrasound
ultrasound
4 ultrasound examinations during pregnancy and every time a blood sample is colletted. blood sample from the mother and the umbilical cord is collected as well
Interventions
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ultrasound
4 ultrasound examinations during pregnancy and every time a blood sample is colletted. blood sample from the mother and the umbilical cord is collected as well
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
50 Years
FEMALE
Yes
Sponsors
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Region Zealand
OTHER
University of Copenhagen
OTHER
Zealand University Hospital
OTHER
Responsible Party
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Dorte Nymark Brask
MD, phd student
Principal Investigators
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Estrid Høgdall, PhD leader
Role: STUDY_DIRECTOR
Dept of Pathology Herlev Hospital, Denmark
Julia S. Johansen, Dr med prof
Role: STUDY_DIRECTOR
Dept. of oncology and medicine, Herlev Hospital, Denmark
Locations
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Gynækologisk-Obstetrisk Afdeling, Sygehus Nord
Roskilde, Region Sjælland, Denmark
Countries
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References
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Gybel-Brask D, Hogdall E, Johansen J, Christensen IJ, Skibsted L. Serum YKL-40 and uterine artery Doppler -- a prospective cohort study, with focus on preeclampsia and small-for-gestational-age. Acta Obstet Gynecol Scand. 2014 Aug;93(8):817-24. doi: 10.1111/aogs.12432. Epub 2014 Jun 20.
Other Identifiers
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SJ-55
Identifier Type: -
Identifier Source: org_study_id