Trial Outcomes & Findings for Memantine Treatment of Compulsive Buying (NCT NCT00830375)

Results Overview

The CB-YBOCS is a reliable and valid, 10-item, clinician-administered scale that rates buying symptoms within the last seven days, on a severity scale from 0 to 4 for each item (total scores range from 0 to 40 with higher scores reflecting greater illness severity). Scores ranging from 0 to 10 reflect minimal or mild symptoms; scores from 11 to 20 suggest moderate symptoms; severe symptoms are associated with scores from 21 to 30; and scores greater than 30 reflect extreme buying symptoms

Recruitment status

COMPLETED

Study phase

PHASE2

Target enrollment

10 participants

Primary outcome timeframe

from study start to study end (8-weeks) and is Investigator rated

Results posted on

2019-07-29

Participant Flow

December 2008 - August 2010

Participant milestones

Participant milestones
Measure	Memantine 10-30mg tablets of memantine taken once daily by mouth
Overall Study STARTED	10
Overall Study COMPLETED	9
Overall Study NOT COMPLETED	1

Reasons for withdrawal

Reasons for withdrawal
Measure	Memantine 10-30mg tablets of memantine taken once daily by mouth
Overall Study Lost to Follow-up	1

Baseline Characteristics

Memantine Treatment of Compulsive Buying

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Memantine n=10 Participants 10-30mg tablets of memantine taken once daily by mouth
Age, Categorical <=18 years	0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	10 Participants n=5 Participants
Age, Categorical >=65 years	0 Participants n=5 Participants
Age, Continuous	32 years STANDARD_DEVIATION 12.4 • n=5 Participants
Sex: Female, Male Female	9 Participants n=5 Participants
Sex: Female, Male Male	1 Participants n=5 Participants
Region of Enrollment United States	10 participants n=5 Participants

PRIMARY outcome

Timeframe: from study start to study end (8-weeks) and is Investigator rated

Population: Reported scores are Mean and standard deviation for Subjects last visit (Week 8 or last-observation carried forward).

The CB-YBOCS is a reliable and valid, 10-item, clinician-administered scale that rates buying symptoms within the last seven days, on a severity scale from 0 to 4 for each item (total scores range from 0 to 40 with higher scores reflecting greater illness severity). Scores ranging from 0 to 10 reflect minimal or mild symptoms; scores from 11 to 20 suggest moderate symptoms; severe symptoms are associated with scores from 21 to 30; and scores greater than 30 reflect extreme buying symptoms

Outcome measures

Outcome measures
Measure	Memantine n=10 Participants 10-30mg tablets of memantine taken once daily by mouth
Yale Brown Obsessive Compulsive Scale Modified for CB (CB-YBOCS)	22 units on a scale Standard Deviation 4

Adverse Events

Memantine

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Jon E. Grant

University of Minnesota

Phone: 612-273-9800

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place