Safety of Gadovist in Renally Impaired Patients

NCT ID: NCT00828737

Last Updated: 2016-02-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

927 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-12-31

Study Completion Date

2015-01-31

Brief Summary

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Patients with moderate to severe renal impairment scheduled for a magnetic resonance imaging (MRI) scan and injection with a contrast agent, Gadovist, will be asked to participate.

The administration of contrast agents that contain gadolinium such as Gadovist might increase a potential risk to develop a rare condition called nephrogenic systemic fibrosis (NSF) in patients with renal impairment. This study is to assess the potential risk to develop NSF in patients with renal impairment after the administration of Gadovist. Patients who are enrolled in this study will receive a Gadovist enhanced MRI scan which was prescribed by the referring doctor. After the MRI scan the patient will be included in a two year follow-up period to assess if signs or symptoms suggestive of NSF have appeared.

Detailed Description

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Conditions

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Fibrosis Renal Impairment

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm 1

Group Type EXPERIMENTAL

Gadobutrol (Gadovist, BAY86-4875)

Intervention Type DRUG

Gadovist in approved indications at approved dosages

Interventions

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Gadobutrol (Gadovist, BAY86-4875)

Gadovist in approved indications at approved dosages

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with moderate (eGFR 30 - 59 ml/min/173m2) or severe (eGFR \< 30 ml/min/1.73m2) renal impairment, scheduled to undergo Gadovist-enhanced MRI

Exclusion Criteria

* GBCA-enhanced MRI (or administration of a GBCA for any other CE imaging procedure) other than Gadovist within 12 months prior to administration of Gadovist
* History of NSF (Nephrogenic Fibrosing Dermopathy)
* Age outside the indicated age range mentioned in national labelling.
Minimum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Adelaide, South Australia, Australia

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Clayton, Victoria, Australia

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Geelong, Victoria, Australia

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Westmead NSW, , Australia

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Innsbruck, Tyrol, Austria

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Ehenbichl, , Austria

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Graz, , Austria

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Leoben, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Calgary, Alberta, Canada

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Hamilton, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Fleurimont, Quebec, Canada

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Le Kremlin-Bicêtre, , France

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Lille, , France

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Marseille, , France

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Paris, , France

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Reims, , France

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Mannheim, Baden-Wurttemberg, Germany

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Tübingen, Baden-Wurttemberg, Germany

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Coburg, Bavaria, Germany

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Erlangen, Bavaria, Germany

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München, Bavaria, Germany

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Regensburg, Bavaria, Germany

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Neuruppin, Brandenburg, Germany

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Hamburg, City state of Hamburg, Germany

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Frankfurt am Main, Hesse, Germany

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Hannoversch Münden, Lower Saxony, Germany

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Osnabrück, Lower Saxony, Germany

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Dortmund, North Rhine-Westphalia, Germany

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Essen, North Rhine-Westphalia, Germany

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Lüdenscheid, North Rhine-Westphalia, Germany

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Dresden, Saxony, Germany

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Leipzig, Saxony, Germany

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Magdeburg, Saxony-Anhalt, Germany

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Berlin, State of Berlin, Germany

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Berlin, State of Berlin, Germany

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Gera, Thuringia, Germany

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Rozzano, Milano, Italy

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Ancona, , Italy

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Brescia, , Italy

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Florence, , Italy

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Genova, , Italy

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Milan, , Italy

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Milan, , Italy

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Napoli, , Italy

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Pisa, , Italy

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Roma, , Italy

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Roma, , Italy

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Torino, , Italy

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Treviso, , Italy

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Verona, , Italy

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Seongnam-si, Gyeonggido, South Korea

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Seoul, Seoul Teugbyeolsi, South Korea

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Busan, , South Korea

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Jeonju-Si, Jeonrabuk-Do, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Seoul, , South Korea

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Barcelona, Barcelona, Spain

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Sabadell, Barcelona, Spain

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Granada, Granada, Spain

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Basel, Canton of Basel-City, Switzerland

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Lugano, Canton Ticino, Switzerland

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Bangkok, , Thailand

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Bangkok, , Thailand

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Songkhla, , Thailand

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Countries

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Australia Austria Canada France Germany Italy South Korea Spain Switzerland Thailand

Related Links

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http://www.clinicaltrialsregister.eu/

Click here to find information about studies related to Bayer Healthcare products conducted in Europe

Other Identifiers

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2008-004496-22

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

13273

Identifier Type: -

Identifier Source: org_study_id

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