Open-Label, Long-Term Treatment Study, to Assess the Long-Term Safety and Tolerability and Efficacy of Neramexane in Patients With Subjective Tinnitus

NCT ID: NCT00827008

Last Updated: 2012-11-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE3

Total Enrollment

821 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2011-12-31

Brief Summary

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The purpose of this study is to investigate the long-term safety and tolerability and efficacy of neramexane mesylate in the long-term treatment of subjective tinnitus after a completed double-blind randomized placebo controlled study

Detailed Description

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Conditions

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Subjective Tinnitus

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1, verum

Group Type EXPERIMENTAL

Neramexane mesylate

Intervention Type DRUG

Up-titration treatment period of 5 weeks up to 75mg Neramexane mesylate oral per day followed by 49 weeks treatment maintenance

Interventions

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Neramexane mesylate

Up-titration treatment period of 5 weeks up to 75mg Neramexane mesylate oral per day followed by 49 weeks treatment maintenance

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female patients who have successfully completed one of the double-blind Phase 3 tinnitus studies of Merz with Neramexane mesylate
* patients aged equal or older 18 but not older than 75 years with clinical diagnosis of first onset, persistent (i.e. tinnitus should never be absent for more than 24 hours in a row), subjective, uni-or bilateral subacute tinnitus at the timepoint of the lead-in study

Exclusion Criteria

* clinical diagnosis of intermittent or pulsatile tinnitus
* Patients who have tinnitus as a concomitant symptom of an otological/neurological disease (such as otitis media, Meniére´s disease, otosclerosis etc.)
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Merz Pharmaceuticals GmbH

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Expert

Role: STUDY_DIRECTOR

Merz Pharmaceuticals

Locations

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Paradigm Clinical Research

Tucson, Arizona, United States

Site Status

Providence Clinical Research

Burbank, California, United States

Site Status

Central California Clinical Research

Fresno, California, United States

Site Status

UC Davis Health System Department of Otolaryngology

Sacramento, California, United States

Site Status

Colorado Otolaryngology Associates

Colorado Springs, Colorado, United States

Site Status

New West Physicians

Golden, Colorado, United States

Site Status

Visions Clinical Research

Boynton Beach, Florida, United States

Site Status

Clinical Research of West Florida

Tampa, Florida, United States

Site Status

Deerpath Physicians Group

Gurnee, Illinois, United States

Site Status

Knight Center for Integrated Health,

Peoria, Illinois, United States

Site Status

University of Kansas Department of Otolaryngology Head & Neck Surgery

Kansas City, Kansas, United States

Site Status

Heartland Research Associates, LLC.

Wichita, Kansas, United States

Site Status

Heartland Research Associates, LLC.

Wichita, Kansas, United States

Site Status

Commonwealth Ear, Nose & Throat

Louisville, Kentucky, United States

Site Status

Glacier Ear, Nose, and Throat, Head and Neck Surgery, P.C.

Kalispell, Montana, United States

Site Status

Immedicenter

Bloomfield, New Jersey, United States

Site Status

David L. Bortniker, M.D, FACS

Somerville, New Jersey, United States

Site Status

Erie County Medical Center, Department of Rehabilitation Medicine

Buffalo, New York, United States

Site Status

Montefiore Medical Center Attn: Anxiety and Depression Center

The Bronx, New York, United States

Site Status

Cary Medical Research

Cary, North Carolina, United States

Site Status

Wake Research Associates, LLC

Raleigh, North Carolina, United States

Site Status

Wilmington Medical Research

Wilmington, North Carolina, United States

Site Status

Piedmont Medical Research

Winston-Salem, North Carolina, United States

Site Status

Medical University of South Carolina - Department of Otolaryngology, Department of Otolaryngology - Head & Neck Surgery

Charleston, South Carolina, United States

Site Status

Future Search Trials of Neurology

Austin, Texas, United States

Site Status

FutureSearch Trials of Dallas

Dallas, Texas, United States

Site Status

R/D Clinical Research, Inc.

Lake Jackson, Texas, United States

Site Status

South Texas Research Alliance LLC

Laredo, Texas, United States

Site Status

Research Across America

Plano, Texas, United States

Site Status

Advanced Clinical Research

West Jordon, Utah, United States

Site Status

Health Research of Hampton Roads, Inc.

Newport News, Virginia, United States

Site Status

Krankenhaus der Elisabethinen

Graz, , Austria

Site Status

Bezirkskrankenhaus Kufstein Dr. Christof Pauli (PI: Prim. Dr. Peter Ostertag

Kufstein, , Austria

Site Status

Clin Pharm International GmbH, Zentrum Wien

Vienna, , Austria

Site Status

University Hospital Brussels

Brussels, , Belgium

Site Status

Clinique Universitaire Saint-luc

Brussels, , Belgium

Site Status

AZ Sint Lucas, ENT department

Ghent, , Belgium

Site Status

University Hospital Leuven, ENT Department

Leuven, , Belgium

Site Status

Consultório Dr. Marcelo Rates

Belo Horizonte/Mimaf Gerais, , Brazil

Site Status

Osmar Clayton Person

Santo André/SP, , Brazil

Site Status

Instituto Ganz Sanchez

São Paulo/SP, , Brazil

Site Status

Clínica OTOSUL

Valenca/RJ, , Brazil

Site Status

Medico

Chodov, Prague, Czechia

Site Status

prof. MUDr. Ivo Šlapák

Brno, , Czechia

Site Status

Teaching University Hospital, ORL klinika

Brno, , Czechia

Site Status

ORL oddělení, Karlovarská krajská nemocncie a.s.

Karlovy Vary, , Czechia

Site Status

Oblastní nemocnice Kladno a.s., Nemocnice Středočeského kraje

Kladno, , Czechia

Site Status

Pro-audio,s.r.o.-private ENT clinic

Mladá Boleslav, , Czechia

Site Status

ORL oddělení, Všeobecná Fakultní Nemocnice v Praze

Prague, , Czechia

Site Status

ORL oddělení , Karlovarská krajská nemocnice a. s.

Sokolov, , Czechia

Site Status

Dr. Ebbo

Issy-les-Moulineaux, , France

Site Status

Dr. Sarfati

La Seyne-sur-Mer, , France

Site Status

Centre Hospitalier de Bretagne Sud Service ORL-B9

Lorient, , France

Site Status

Dr. Bonfils

Paris, , France

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Dr. Ohresser

Paris, , France

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Hopital Nord

Saint-Etienne, , France

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Dr. Fraysse

Toulouse, , France

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Service ORL CHU Bretonneau

Tours, , France

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Hopital Paul BROUSSE Polyclinique

Villejuif, , France

Site Status

Dr. Kühne, Elisabeth

Halle, Saale, Germany

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Dr. med. Norbert Pasch

Aachen, , Germany

Site Status

Charité, Universitätsmedizin Berlin-Tinnituszentrum

Berlin, , Germany

Site Status

Klin. Forschung Berlin Buch GmbH

Berlin, , Germany

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Dr. med. Frank Reintjes

Braunschweig, , Germany

Site Status

DM Helena Sigal

Chemnitz, , Germany

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Dr. Klaus Peter Jayme

Darmstadt, , Germany

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Dr. Christian Dörr

Dresden, , Germany

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HNO-Praxis im Gesundheitszentrum

Duisburg, , Germany

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Dr. Gieselmann, Werner

Heiligenhaus, , Germany

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Dr. Wolfgang Lotte

Iserlohn, , Germany

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Dr. Dr. med. Hans-Detlev Stahl

Leipzig, , Germany

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HNO Praxis

Lichtenfels, , Germany

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Dr. Dannesberger

Lorsch, , Germany

Site Status

ClinPharm International

Magdeburg, , Germany

Site Status

HNO Gemeinschaftpraxis

Meppen, , Germany

Site Status

Martin Canis, MD

Munich, , Germany

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Dr. med. Ulrike Walter

Nuremberg, , Germany

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Dr. Susanne Wiedemann

Nuremberg, , Germany

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Dr. Norbert Staab

Schlüchtern, , Germany

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Dr. Hannelore Neumaier

Wiesbaden, , Germany

Site Status

Unidad Médica de Especialidades del Noroeste (UMEN)

Centro Culiacán Sinaloa, , Mexico

Site Status

Hospital General de Chihuahua. "Dr. Salvador Anchondo"

Chihuahua C.P. 31000, , Mexico

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Hospital Christus Muguerza del Parque

Chihuahua CP 3100, , Mexico

Site Status

Internal Medicine Clin Trials (IMED)

Col Obispado, Monterrey , N.L. C.P. 64060, , Mexico

Site Status

Hospital Civil de Guadalajara

Col. El Retiro CP 44280 Cuadalajara Jalis, , Mexico

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Grupo Médico Terranova

CP 44630 Guadalajara Jalisco, , Mexico

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Clinical Research Instutute S.C.

Edo. de México CP 54055, , Mexico

Site Status

Instituto Biomédico de Investigación A.C.

Fracc. Bosques Del Prado Norte Aguascalientes, , Mexico

Site Status

Unidad de Investigación Clínica Cardiometábolica de Occidente S.C. (UNICAMO)

Jalisco, , Mexico

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Monterrey International Research Center (MIRC)

Nuevo León CP 64000, , Mexico

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Hospital Universitario Dr. José Eleuterio González. Edificio Elizondo Barragán, Servicio de Otorrinolaringología

Nuevo León CP 64400, , Mexico

Site Status

Hospital Central "Dr. Ignacio Morones Prieto" Servicio de Otorrinolaringología

San Luis Potosí, SLP, México, 78240, , Mexico

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Andromed Zoetermeer

Zoetermeer, EK, Netherlands

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Andromed Oost

Velp, ES, Netherlands

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Rijnland Ziekenhuis, ENT department

Leiderdorp, GA, Netherlands

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Andromed Rotterdam

Rotterdam, HC, Netherlands

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Adromed Nijmegen

Nijmegen, HL, Netherlands

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Andromed Leiden

Leiderdorp, RA, Netherlands

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Andromed Breda

Breda, VL, Netherlands

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Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, , Poland

Site Status

Niepubliczny Zaklad Opieki Zdrowotnej Prywatne Centrum Medyczne PROMEDIS

Gdansk, , Poland

Site Status

Szpital Miejski im. J.Brudzinskiego

Gdynia, , Poland

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Samodzielny Publiczny Szpital Kliniczny im. Andrzeja Mieleckiego Slaskiego Uniwersytetu Medycznego w Katowicach

Katowice, , Poland

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NZOZ Specjalistyczne Centrum Medyczne Nowomed

Krakow, , Poland

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Niepubliczny Zaklad Opieki Zdrowotnej PROMED

Krakow, , Poland

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Specjalistyczny Gabinet Otolaryngologiczny

Krakow, , Poland

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Szpital Specjalistyczny im. Stefana Zeromskiego, SP ZOZ w Krakowie, Oddzial Otolaryngologii

Krakow, , Poland

Site Status

Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi

Lodz, , Poland

Site Status

Wojewodzki Szpital Specjalistyczny im. Stefana Kardynała Wyszynskiego Samodzielny Publiczny Zaklad Opieki Zdrowotnej

Lublin, , Poland

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Wojewodzki Szpital Specjalistyczny w Olsztynie

Olsztyn, , Poland

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Instytut Fizjologii i Patologii Sluchu

Warsaw, , Poland

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Samodzielny Publiczny Szpital Kliniczny nr 1 we Wroclawiu

Wroclaw, , Poland

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Hospital Militar Regional nº 1 Serviço de Otorrinolaringologia

Porto, , Portugal

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Louis Leipoldt Mediclinic

Bellville, , South Africa

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Lakeview Hospital

Benoni, , South Africa

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1007 Louis Pasteur Building

Pretoria, , South Africa

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GCT Eastmed Clinical Trial centre

Pretoria, , South Africa

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Constantiaberg Medi Clinic,

Western Cape, , South Africa

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Prince Alfred House

Wynberg, , South Africa

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Hospital Sagunto

Sagunto, Valencia, Spain

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Fundación Hospital de Alcorcón, Otorhinolaryngology

Alcorcon - Madrid, , Spain

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Hospital Clínico Barcelona, Dept. Of ORL

Barcelona, , Spain

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Hospital Puerta del Hierro, Madrid- Servicio de ORL

Madrid, , Spain

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Hospital Universitario Príncipe de Asturias

Madrid, , Spain

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Clínica Universitaria de Navarra, Dept. ORL

Pamplona, Navarra, , Spain

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Hospital Universitario de Salamanca- Hospital Virgen de la Vega

Salamanca, , Spain

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Oldfield Surgery

Bath, , United Kingdom

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Addenbrooke's Hospital

Cambridge, , United Kingdom

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Avondale Surgery, Research Office

Chesterfield, , United Kingdom

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The university Hospitals of Leicester, Leicester Royal Infirmary

Leicester, , United Kingdom

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Burbage Surgery

Leicestershire, , United Kingdom

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The Freeman Hospital

Newcastle upon Tyne, , United Kingdom

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Wansford and Kings Cliffe Practice

Petereborough, , United Kingdom

Site Status

Frome Medical Practice

Somerset, , United Kingdom

Site Status

Sherbourne Medical Centre

Warwickshire, , United Kingdom

Site Status

Countries

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United States Austria Belgium Brazil Czechia France Germany Mexico Netherlands Poland Portugal South Africa Spain United Kingdom

Other Identifiers

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2008-001432-13

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

MRZ 92579/TI/3004

Identifier Type: -

Identifier Source: org_study_id