Influence of Vitamin-B-complex on Cognitive Ability of Kindergarten Kids

NCT ID: NCT00811291

Last Updated: 2012-07-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-30

Study Completion Date

2011-12-31

Brief Summary

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Vitamin-B and Folic intake of Kindergarten kids in Germany is only 50-70% of the official recommendations. In studies with adults it has been found that for example providing people suffering from Alzheimer´s disease improved their mental and cognitive abilities when provided with a high intake of these vitamins.The hypothesis is, that kindergarten kids, 4-6 years of age, could also improve mentally from a recommended intake of B-vitamins and Folic Acid.

1. screening study: The urine of 1200 kindergarten kids will be analyzed for metabolites of these vitamins, and the 250 kids with the lowest results will be invited for a randomized double blind intervention study.
2. intervention study: Participating kids will get an one hour mental and cognitive testing before and after the intervention. The intervention will be one portion of the recommended dosage of a vitamin B complex and folic acid , given in a drink (milk, tea, etc). The assumption is, that the treatment group will perform better than the placebo group in the second test phase.

Detailed Description

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Conditions

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Healthy

Keywords

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B-vitamins Folic-Acid kindergarten kids cognitive tests Healthy kids second part low urine vitamine-B-metabolites

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Group Type PLACEBO_COMPARATOR

calcium

Intervention Type DIETARY_SUPPLEMENT

according to protocol

2

folic acid and B-vitamin supplement

Group Type ACTIVE_COMPARATOR

Vitamine-B and Folic Acid Complex, calcium

Intervention Type DIETARY_SUPPLEMENT

90 days of intake, will be given in drink (e.g. tea, milk, juice). Dosage within official recommendations for kindergarten kids

Interventions

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Vitamine-B and Folic Acid Complex, calcium

90 days of intake, will be given in drink (e.g. tea, milk, juice). Dosage within official recommendations for kindergarten kids

Intervention Type DIETARY_SUPPLEMENT

calcium

according to protocol

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* age: 4-6 years
* kindergarten kids in Munich
* fluent in German
* healthy
* no medication

Exclusion Criteria

* not fluent in German
* chronic illness
* intake of multivitamin supplements
Minimum Eligible Age

4 Years

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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European Union

OTHER

Sponsor Role collaborator

Unilever R&D

INDUSTRY

Sponsor Role collaborator

Ludwig-Maximilians - University of Munich

OTHER

Sponsor Role lead

Responsible Party

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Koletzko - Office

Professor Berthold Koletzko

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Berthold V Koletzko, M.D., PhD

Role: PRINCIPAL_INVESTIGATOR

Dr. von Hauner Children´s Hospital, Ludwig-Maximilians-University, Munich

Locations

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Dr. von Hauner Children´s Hospital

Munich, , Germany

Site Status

Countries

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Germany

Other Identifiers

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08032V

Identifier Type: -

Identifier Source: org_study_id