The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis

NCT ID: NCT00808496

Last Updated: 2011-10-07

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE4
• Total Enrollment: 186 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-06-30
• Study Completion Date: 2013-04-30

Brief Summary

Inflammatory arthritis is a major cause of permanent joint damage. Joint damage causes functional disability and physical deformity. Many inflammatory arthritis patients develop permanent joint damage within the first two years of disease. Early, aggressive treatment with drugs called disease-modifying antirheumatic drugs (DMARDs) is known to reduce how quickly this damage occurs. Sometimes, however, even when patients' symptoms are under control, the disease continues to cause joint damage.

This study will determine if magnetic resonance imaging (also known as 'MRI') conducted every six months provides arthritis specialists with information to help them better treat peripheral inflammatory arthritis patients over the first two years of care. The effect of MRI will be compared to 1) the use of x-ray every six months; and, 2) the frequency at which these tests are usually used. The study will also determine if differences in treatment between the three groups result in differences in the well-being of patients.

A total of 186 patients with early signs of inflammatory arthritis will be studied. All participants will have an MRI and x-ray conducted every six months. One-third of participants (62 in total) will only have MRI information sent to their arthritis specialist (MRI group); 62 will have x-ray information sent (X-ray group); and, the remaining 62 will have x-ray information sent only when ordered by the arthritis specialist (Usual Care group). Negative disease progression reports will be sent to the arthritis specialist unless intervention allocation-specific disease progression is detected. In which case, a report blinded to imaging modality will be sent indicating the detection of disease progression relative to the last timepoint of progression, or baseline, as applicable. At any point in the study, the arthritis specialist can request a clinical MRI or x-ray for any participant.

Neither the participants nor their doctors will know to which group they are assigned. A computer program will randomly assign participants to one of the three groups using a technique called minimization. This technique accounts for differences between participants that are known to effect disease progression and treatment decisions. Using this technique, participants with similar disease will be evenly distributed between the three groups.

The results of this study will have a direct impact on care for new inflammatory arthritis patients. It will determine the benefits, if any, of regular monitoring of disease progression with MRI or x-ray. Using tests proven to help treatment decision-making, arthritis specialists will improve the care provided to new inflammatory arthritis patients.

Detailed Description

The proposed project is a double-blinded randomized-controlled trial to determine if biannual monitoring of inflammatory arthritis disease progression with 1.0T peripheral magnetic resonance imaging (pMRI) of the 2nd to 5th metacarpophalangeal joints of the worst-effected or dominant hand at baseline compared to conventional radiography of both hands and wrists, or standard of care, alters the frequency of pharmacological treatment escalation at two years. A sample size of 186 (62 per group) is required to determine mean differences in the rate of pharmacological treatment escalation between the three groups with 90% power at a 5% level of significance, assuming a 5% spontaneous remission rate, 15% missing data, and 5% annual attrition.

Conditions

Inflammatory Arthritis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: QUADRUPLE

Study Groups

MRI

Biannual disease progression monitoring with peripheral magnetic resonance imaging of the 2nd to 5th metacarpophalangeal joints of the worst-effected or dominant hand at baseline.

Group Type: EXPERIMENTAL

MRI

Intervention Type: OTHER

Biannual disease progression monitoring with peripheral magnetic resonance imaging of the 2nd to 5th metacarpophalangeal joints of the worst-effected or dominant hand at baseline. Scored using the Xie-modified rheumatoid arthritis magnetic resonance imaging score (RAMRIS).

MRI intervention group also undergoes radiography imaging. Only protocol determined smallest detectable changes on MRI reported.

Radiography

Biannual disease progression monitoring with radiography of both hands and wrists.

Group Type: ACTIVE_COMPARATOR

Radiography

Intervention Type: OTHER

Biannual disease progression monitoring with radiography of both hands and wrists. Scored using the van der Heijde-modified Sharp score.

Radiography intervention group also undergoes MRI imaging. Only protocol determined smallest detectable changes on radiography reported.

Standard of Care

Diagnostic imaging results (MRI or radiography) reported to upon requisition.

Group Type: PLACEBO_COMPARATOR

Standard of Care

Intervention Type: OTHER

Diagnostic imaging results (MRI or radiography) reported upon requisition. Standard of Care intervention group undergoes both MRI and radiography imaging. Upon requisition of either MRI or radiography, radiology reports are delivered as per institutional standard of care

Interventions

MRI

Biannual disease progression monitoring with peripheral magnetic resonance imaging of the 2nd to 5th metacarpophalangeal joints of the worst-effected or dominant hand at baseline. Scored using the Xie-modified rheumatoid arthritis magnetic resonance imaging score (RAMRIS).

MRI intervention group also undergoes radiography imaging. Only protocol determined smallest detectable changes on MRI reported.

Intervention Type: OTHER

Radiography

Biannual disease progression monitoring with radiography of both hands and wrists. Scored using the van der Heijde-modified Sharp score.

Radiography intervention group also undergoes MRI imaging. Only protocol determined smallest detectable changes on radiography reported.

Intervention Type: OTHER

Standard of Care

Diagnostic imaging results (MRI or radiography) reported upon requisition. Standard of Care intervention group undergoes both MRI and radiography imaging. Upon requisition of either MRI or radiography, radiology reports are delivered as per institutional standard of care

Intervention Type: OTHER

Other Intervention Names

Diagnostic imaging: 1T pMRI (OrthOne, ONI Medical Systems); Diagnostic Imaging: Conventional radiography.; Placebo control: see MRI and radiography interventions.

Eligibility Criteria

Inclusion Criteria

• At least 18 years of age at study enrollment.
• At least three swollen joints; OR,
• Metacarpophalangeal joint(s) positive squeeze test; OR,
• Metatarsophalangeal joint(s) positive squeeze test; OR,
• At least 30 minutes of self-reported morning stiffness.
• At least six weeks of self-reported symptom duration.

Exclusion Criteria

• Self-reported symptom onset prior to 17 years of age.
• Medical history of juvenile arthritis
• Evidence of viral arthritis
• A concomitant condition with medical priority over inflammatory arthritis, or that contraindicates treatment with DMARDs excluding sulfa allergy or medically controlled, non-terminal liver disease.
• Refusal to receive DMARD treatment
• Patients with a psychological deficit, or diminished capacity to provide independent, informed consent
• Any contraindication to MRI or x-ray
• Current or planned pregnancy
• Lactation

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

Ruben Tavares

PhD Candidate

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ruben Tavares, MBt MSc CCRA

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Jonathan D Adachi, MD FRCPC

Role: STUDY_CHAIR

McMaster University

Maggie J Larche, MD PhD

Role: STUDY_DIRECTOR

McMaster University

Colin E Webber, PhD CCPM

Role: STUDY_DIRECTOR

McMaster University

Naveen Parasu, MD FRCPC

Role: STUDY_DIRECTOR

McMaster University

Karen A Beattie, PhD

Role: STUDY_DIRECTOR

McMaster University

Locations

McMaster University, Division of Rheumatology

Hamilton, Ontario, Canada

Countries

Canada

References

Brown AK, Conaghan PG, Karim Z, Quinn MA, Ikeda K, Peterfy CG, Hensor E, Wakefield RJ, O'Connor PJ, Emery P. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum. 2008 Oct;58(10):2958-67. doi: 10.1002/art.23945.

Reference Type: BACKGROUND

PMID: 18821687 (View on PubMed)

Schiff MH, Hobbs KF, Gensler T, Keenan GF. A retrospective analysis of low-field strength magnetic resonance imaging and the management of patients with rheumatoid arthritis. Curr Med Res Opin. 2007 May;23(5):961-8. doi: 10.1185/030079907x178892.

Reference Type: BACKGROUND

PMID: 17519063 (View on PubMed)

McQueen FM, Stewart N, Crabbe J, Robinson E, Yeoman S, Tan PL, McLean L. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. Ann Rheum Dis. 1999 Mar;58(3):156-63. doi: 10.1136/ard.58.3.156.

Reference Type: BACKGROUND

PMID: 10364913 (View on PubMed)

Olech E, Freeston JE, Conaghan PG, Hensor EM, Emery P, Yocum D. Using extremity magnetic resonance imaging to assess and monitor early rheumatoid arthritis: the optimal joint combination to be scanned in clinical practice. J Rheumatol. 2008 Apr;35(4):580-3. Epub 2008 Mar 1.

Reference Type: BACKGROUND

PMID: 18322995 (View on PubMed)

Xie X, Webber CE, Adachi JD, O'Neill J, Inglis D, Bobba RS, Wu H. Quantitative, small bore, 1 Tesla, magnetic resonance imaging of the hands of patients with rheumatoid arthritis. Clin Exp Rheumatol. 2008 Sep-Oct;26(5):860-5.

Reference Type: BACKGROUND

PMID: 19032820 (View on PubMed)

van der Heijde DM, van Riel PL, Nuver-Zwart IH, Gribnau FW, vad de Putte LB. Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis. Lancet. 1989 May 13;1(8646):1036-8. doi: 10.1016/s0140-6736(89)92442-2.

Reference Type: BACKGROUND

PMID: 2565997 (View on PubMed)

Taves DR. Minimization: a new method of assigning patients to treatment and control groups. Clin Pharmacol Ther. 1974 May;15(5):443-53. doi: 10.1002/cpt1974155443. No abstract available.

Reference Type: BACKGROUND

PMID: 4597226 (View on PubMed)

Saag KG, Teng GG, Patkar NM, Anuntiyo J, Finney C, Curtis JR, Paulus HE, Mudano A, Pisu M, Elkins-Melton M, Outman R, Allison JJ, Suarez Almazor M, Bridges SL Jr, Chatham WW, Hochberg M, MacLean C, Mikuls T, Moreland LW, O'Dell J, Turkiewicz AM, Furst DE; American College of Rheumatology. American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum. 2008 Jun 15;59(6):762-84. doi: 10.1002/art.23721. No abstract available.

Reference Type: BACKGROUND

PMID: 18512708 (View on PubMed)

Emery P, Breedveld FC, Dougados M, Kalden JR, Schiff MH, Smolen JS. Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide. Ann Rheum Dis. 2002 Apr;61(4):290-7. doi: 10.1136/ard.61.4.290.

Reference Type: BACKGROUND

PMID: 11874828 (View on PubMed)

Tavares R, Beattie KA, Bensen WG, Bobba RS, Cividino AA, Finlay K, Goeree R, Hart LE, Jurriaans E, Larche MJ, Parasu N, Tarride JE, Webber CE, Adachi JD. A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial. Trials. 2014 Jul 5;15:268. doi: 10.1186/1745-6215-15-268.

Reference Type: DERIVED

PMID: 24997587 (View on PubMed)

Other Identifiers

200901

Identifier Type: -

Identifier Source: org_study_id