Study the Effects of CYP2C Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Glipizide

NCT ID: NCT00806013

Last Updated: 2010-01-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

36 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-08-31

Study Completion Date

2008-12-31

Brief Summary

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The aims of this study were to investigate the effects of CYP2C9 and CYP2C19 polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in healthy Chinese subjects.

Detailed Description

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Compared with CYP2C19, CYP2C9 polymorphism appears to have a dominant role in glipizide pharmacokinetics and pharmacodynamics in vivo. This indicated that dose adjustment based on CYP2C9 genotype may improve antidiabetic treatment.

Conditions

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Healthy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

CYP2C9\*1/\*1 and CYP2C19\*1/\*1 alleles carrier

No interventions assigned to this group

2

CYP2C19 PMs (CYP2C19\*2/\*2, CYP2C19\*2/\*3 or CYP2C19\*3/\*3)

No interventions assigned to this group

3

CYP2C9\*1/\*3 and CYP2C19\*1/\*1 alleles carrier

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* nonsmokers and in good health

Exclusion Criteria

* family history of diabetes mellitus
* taking any drug, alcohol, foods containing caffeine, or grapefruits and juice before study
Minimum Eligible Age

21 Years

Maximum Eligible Age

27 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Chinese Academy of Sciences

OTHER_GOV

Sponsor Role lead

Principal Investigators

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Bo Tan

Role: PRINCIPAL_INVESTIGATOR

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Locations

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The second hospital to Liaoning University of TCM

Shenyang, Liaoning, China

Site Status

Countries

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China

Related Links

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http://english.cas.cn/

Chinese Academy of Sciences

http://www.lnutcm.edu.cn/en/

Liaoning University of TCM

Other Identifiers

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SIMM-080601

Identifier Type: -

Identifier Source: org_study_id

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