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Acquired Von Willebrand Syndrome in Severe Aortic Stenosis

NCT ID: NCT00805051

Last Updated: 2011-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-10-31

Study Completion Date

2010-08-31

Brief Summary

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Patients with severe aortic stenosis often suffer from an acquired Von Willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. We hypothesized that the diagnosis of acquired von Willebrand syndrome influence perioperative blood loss in patients undergoing open cardiac valve replacement.

Detailed Description

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Patients with severe aortic stenosis often suffer from an acquired Von Willebrand syndrome by degeneration of the polymers during passage through the narrow valve leading to turbulences. After written consent and an extended anamnesis of existing coagulopathy, we take three blood samples in these patients: before surgery, on the day after surgery and 4 weeks after surgery. We determine von Willebrand factor in lab and by a point-of-care platelet function analyzer (Multiplate TM). We measure amount of mediastinal drainage after 24 hours and blood product consumption in these patients.

Conditions

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Bleeding Von Willebrand Disease Aortic Stenosis

Keywords

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Aortic stenosis aortic valve replacement von Willebrand disease blood loss

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Severe aortic stenosis

Patients undergoing aortic valve replacement because of severe aortic stenosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Severe aortic stenosis (Orifice area \< 1 cm2)

Exclusion Criteria

* missing consent
* severe hepatic or renal disfunction
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Daniel Bolliger

PD Dr. Daniel Bolliger

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Miodrag Filipovic, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Anaesthesia, University of Basel Hospital

Locations

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Department of Anaesthesia, University of Basel Hospital

Basel, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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07/08

Identifier Type: -

Identifier Source: org_study_id