Continuous Glucose Monitoring (CGM) in Subjects With Type 2 Diabetes Taking Twice-Daily Exenatide or Once-Weekly Exenatide

NCT ID: NCT00803920

Last Updated: 2015-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

8 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-12-31

Study Completion Date

2008-02-29

Brief Summary

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The purpose of this substudy is to obtain CGM data from individuals taking exenatide. The CGM measurements gathered before starting and during treatment with exenatide IR and/or exenatide LAR will help determine the characteristics of glucose control during treatment.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Exenatide

No interventions assigned to this group

Exenatide LAR

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* participant in Amylin Protocol 2993LAR-105
* at least 16 years of age
* type 2 diabetes being treated with stable regiment of metformin, SU, TZD, combination of metformin/SU, combination metformin/TZD, combination SU/TZD
* A1c 7.1 - 11
* fasting glucose less than 280 at screening
* BMI 25 - 45
* stable body weight 6 months prior to screening
* not pregnant and willing to practice birth control
* physical exam \& ECG not clinically significant
* lab values judged not to be clinically significant
* able to understand \& sign consent form

Exclusion Criteria

* clinically significant medical condition as judged by investigator
* drug or alcohol abuse
* previous use of exenatide or any GLP-1 analog
* has used any investigational drug in the past 30 days prior to screening
* is currently using: alpha-glucosidase inhibitor, insulin, drugs that affect GI motility, use of systemic corticosteroids, use of medications with addictive potential, prescription or OTC weight-loss medications
* has donated blood within 60 days of screening, or is planning to donate during the study
* has had major surgery or blood transfusion within 2 months of screening
* has had a surgical procedure that may impact gastric emptying
* has any allergies or hypersensitivity to any component of study treatment
* is an immediate family member of personnel affiliated with the study at the investigative site
* is employed by Amylin, Lilly or Alkermes
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Amylin Pharmaceuticals, LLC.

INDUSTRY

Sponsor Role collaborator

HealthPartners Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Richard M Bergenstal, MD

Role: PRINCIPAL_INVESTIGATOR

Park Nicollet Institute dba International Diabetes Center

Elinor S Strock, APRN, BC

Role: PRINCIPAL_INVESTIGATOR

Park Nicollet Institute dba International Diabetes Center

Roger S Mazze, PhD

Role: PRINCIPAL_INVESTIGATOR

Park Nicollet Institute dba International Diabetes Center

Locations

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International Diabetes Center

Minneapolis, Minnesota, United States

Site Status

Countries

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United States

Other Identifiers

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03404-06-C

Identifier Type: -

Identifier Source: org_study_id