Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2008-12-31
2009-05-31
Brief Summary
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Research objectives:
To develop a model to investigate the frequency of influenza transmission from an infected child to a susceptible health care worker
Research Hypotheses:
Influenza viruses can be transmitted from infected children to exposed health care workers
Detailed Description
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subjects will be followed by diary card, clinical symptom scores and virology swabs to assess frequency of transmission
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Heathcare worker
health care worker exposed to patient with influenza
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age \< 16 years
* Parents or legal guardians willing to give informed written consent
* Presenting with a febrile illness confirmed as influenza by near patient rapid antigen testing
* Healthy volunteers
* Willing to give informed written consent
Exclusion Criteria
* No parents or legal guardians able to give informed consent
* Healthy volunteers
* known allergy to oseltamivir or zanamivir
* presence of underlying condition or concomitant therapy requiring dose alteration of oseltamivir (severe renal or hepatic failure; methotrexate and probenecid)
* underlying immunosuppressive disorder
* known galactose intolerance
* underlying chronic medical condition known to increase risk of influenza-related complications (including asthma, chronic pulmonary airways disease, chronic cardiovascular disease, diabetes mellitus, chronic neurological disorder)
* inability or contraindication to collection of nasal swabs
* previous influenza vaccination within 2 years
* current smoker
* pregnancy
18 Years
40 Years
ALL
Yes
Sponsors
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University Hospitals, Leicester
OTHER
Responsible Party
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University of Leicester, UK
Principal Investigators
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Iain Stephenson, FRCP
Role: PRINCIPAL_INVESTIGATOR
University Hospitals, Leicester
Locations
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University Hospitals Leicester
Leicester, Leics, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Iain Stephenson, FRCP
Role: primary
Other Identifiers
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REC 07/H0402/59
Identifier Type: -
Identifier Source: secondary_id
UHL10421
Identifier Type: -
Identifier Source: org_study_id