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Evaluation of Power Doppler US Technique for the Diagnosis of Spondylarthropathy

NCT ID: NCT00794404

Last Updated: 2016-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

489 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-12-31

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this study is to evaluate the interest of enthesis sonography for the diagnosis of spondylarthritis, in patients with uncertain diagnosis consulting for clinical symptoms suggestive of spondylarthritis

Detailed Description

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Spondylarthritis (SPA) are the second most frequent inflammatory rheumatic disorders and, because it starts early in life and has a chronic progressive course, the impact of this disease on health resources and patient's life quality can be important. Because the characteritic signs of SPA, like radiological evidence of sacro-iliitis, appear late in time, the lag time between the onset first signs of SPA for the patient and the confirmed diagnosis can be very long (up to 8 years). Previous studies proved that patients who are affected by SPA are showing abnormal vascularization of peripheral enthesis more frequently than patients affected by other rheumatic diseases. Ultrasonography in B mode combined with power Doppler (PDUS) is a non invasive and highly sensitive toll which can detect enthesitis and abnormal vsacularization even for the patients who are not showing yet the evidence of SPA's symptomatology. Using PDUS as a early diagnosis tool could lead to the improvement of diagnostic procedures and therapeutic management of SpA and reduce the cost of diagnosis for patient and health insurances.

Conditions

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Spondylarthropathy Ankylosing Spondyloarthitis Spondyloarthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients \< 50 years old, consulting for spinal inflammatory symptoms \> 3 months duration
* patients consulting for arthritis or tenderness joints \> 3 months duration
* patients \< 50 years old consulting for enthesitis or dactylitis \> 3 months duration
* patients with uveitis and HLA-B27 positivity
* relatives of SpA patients consulting for symptoms suggestive of SpA

Exclusion Criteria

* patient with confirmed diagnosis of rheumatic disease (included SpA)
* patient protected by law (patient \<18 years old, pregnant woman)
* patient who can't atempt the RMI
* patient who will have difficulties to complete the two years of follow-up
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Groupe Français d'Etude Génétique des Spondylarthropathies

OTHER

Sponsor Role collaborator

French Society of Rheumatology

OTHER

Sponsor Role collaborator

Dr Maria-Atonietta D'AGOSTINO

OTHER

Sponsor Role lead

Responsible Party

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Dr Maria-Atonietta D'AGOSTINO

PU-PH

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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D'AGOSTINO Maria-Antonietta, MCUPH

Role: PRINCIPAL_INVESTIGATOR

Ambroise Paré Hospital

Locations

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Ambroise Paré Hospital

Boulogne-Billancourt, , France

Site Status

Cavale Blanche Hospital

Brest, , France

Site Status

Cote de Nacre Hospital

Caen, , France

Site Status

South Hospital of Grenoble

Échirolles, , France

Site Status

Conception Hospital

Marseille, , France

Site Status

Nancy Brabois Hospital

Vandœuvre-lès-Nancy, , France

Site Status

Countries

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France

References

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Devauchelle-Pensec V, D'Agostino MA, Marion J, Lapierre M, Jousse-Joulin S, Colin D, Chary-Valckenaere I, Marcelli C, Loeuille D, Aegerter P, Guis S, Gaudin P, Breban M, Saraux A; Study Group of Spondylarthritis. Computed tomography scanning facilitates the diagnosis of sacroiliitis in patients with suspected spondylarthritis: results of a prospective multicenter French cohort study. Arthritis Rheum. 2012 May;64(5):1412-9. doi: 10.1002/art.33466.

Reference Type DERIVED
PMID: 22081446 (View on PubMed)

Other Identifiers

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GESPA

Identifier Type: -

Identifier Source: org_study_id