Omega-3 Fatty Acids and Muscle Protein Synthesis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

43 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-06-30

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this study is to determine whether omega-3 fatty acid supplementation influences muscle protein synthesis rates in young and older adults.

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Detailed Description

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Loss of muscle mass is a normal consequence of aging. The decline in muscle mass is estimated to be 0.2-0.5% per year from 60 years old onwards in healthy subjects with the decline worsened by chronic illness, poor appetite and diet, and reduced physical activity in the elderly. Increased morbidity is demonstrable with as little as a 5% loss of muscle mass - therefore, treatments that can prevent or slow the progression of muscle loss with aging are much desired.

A major cause for loss of muscle mass in advanced age appears to be an impaired ability to stimulate the synthesis of muscle protein in response to increased levels of amino acids (the building blocks of proteins) and insulin as occurs after eating because of low-grade inflammation and insulin resistance in muscle of old persons. We propose that long-chain omega-3 polyunsaturated fatty acids (fish oil) slow the loss of muscle mass because fish oil has anti-inflammatory properties and increases the sensitivity of muscle protein synthesis to insulin and amino acids. We will test this by studying the effect of fish oil supplementation on the muscle protein synthesis process in young and older adults.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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A

omega-3 fatty acids

Group Type EXPERIMENTAL

omega-3 fatty acids

Intervention Type DIETARY_SUPPLEMENT

4 grams per day for 8 weeks

B

corn oil

Group Type PLACEBO_COMPARATOR

corn oil

Intervention Type DIETARY_SUPPLEMENT

4 grams per day for 8 weeks

Interventions

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omega-3 fatty acids

4 grams per day for 8 weeks

Intervention Type DIETARY_SUPPLEMENT

corn oil

4 grams per day for 8 weeks

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Lovaza

Eligibility Criteria

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Inclusion Criteria

* Body mass index (BMI) \< 30 kg/m2;
* Age 18-45 yr; or
* Age 65-85 yr

Exclusion Criteria

* Those taking medications known to affect substrate metabolism or medications that may confound the findings from our study (synthetic steroids, glucocorticoids etc.);
* Those with evidence of significant organ system dysfunction (e.g. diabetes mellitis, cirrhosis, hypo- or hyperthyroidism; hypertension);
* Body mass index \> 30 kg/m2
* Age \<18 yr, 45-65 yr or \> 85 yr
* Those performing \>1.5h of exercise/wk

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes