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Investigation of Efficiency of Breathing With Different Breathing Patterns

NCT ID: NCT00784004

Last Updated: 2014-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-11-30

Study Completion Date

2011-06-30

Brief Summary

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Our aim in this study is to investigate the efficiency of the breathing with different breathing patterns. Ten volunteers and twenty patients having respiratory problems will be coached on their breathing through specific masks which will provide four different breathing patterns. These patterns will be 1) Breathing in through the nose only and out through the mouth only 2) Breathing in through the mouth only and out through the nose only 3) Breathing in and out through the nose only 4) Breathing in and out through the mouth only The data obtained from volunteers and patients will be compared within and between the groups.

Detailed Description

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Conditions

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Respiratory Physiology Respiratory Insufficiency Breathing Patterns

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Volunteers

Ten healthy volunteers

Group Type OTHER

Breathing Patterns

Intervention Type OTHER

All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following:

1. Breathing in through the nose only and out through the mouth only
2. Breathing in through the mouth only and out through the nose only
3. Breathing in and out through the nose only
4. Breathing in and out through the mouth only

Patients

Sixteen patients with respiratory insufficiency

Group Type OTHER

Breathing Patterns

Intervention Type OTHER

All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following:

1. Breathing in through the nose only and out through the mouth only
2. Breathing in through the mouth only and out through the nose only
3. Breathing in and out through the nose only
4. Breathing in and out through the mouth only

Interventions

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Breathing Patterns

All subjects will breathe in four different breathing patterns which are provided by specific masks. Patterns are as the following:

1. Breathing in through the nose only and out through the mouth only
2. Breathing in through the mouth only and out through the nose only
3. Breathing in and out through the nose only
4. Breathing in and out through the mouth only

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* For healthy subjects:

1\. Ten healthy adult (\> 18 years of age) volunteers will be recruited from the MGH main campus through intra-hospital e-mail broadcasting. Subjects with the following issues will be excluded from the study.
* For patients with respiratory insufficiency:

1. Twenty adult (\> 18 years of age) patients will be recruited. These patients will be either patients in acute respiratory failure resulting from COPD exacerbation breathing spontaneously only receiving nasal oxygen admitted to the medical floors of the MGH; or patients with diagnosed stable COPD on home oxygen therapy seen by pulmonary physicians in the outpatient clinics or coming to the MGH as study subjects.

Exclusion Criteria

* For healthy volunteers:

1. Subjects with facial deformity, heavy beard or moustache which prevents good seal between the mask and the face;
2. Subjects who have claustrophobia and cannot wear the mask.
* For patients with respiratory insufficiency:

1. Patients with facial deformity, heavy beard or moustache which prevents a good seal between the mask and the face;
2. Patients who have claustrophobia and cannot wear the mask.
3. Patients who are hemodynamically unstable.
4. Patients requiring continuous noninvasive positive pressure ventilation or endotracheal intubation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Massachusetts General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yandong Jiang

Assistant Professor of Anesthesia

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yandong Jiang, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Massachusetts General Hospital

Locations

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Massachusetts General Hospital, Respiratory Care Laboratory

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Sulemanji DS, Bao F, Jiang Y, Kacmarek RM. A unidirectional breathing pattern improves breathing efficiency in subjects with severe COPD. Respir Care. 2014 Oct;59(10):1487-93. doi: 10.4187/respcare.02899. Epub 2014 Apr 29.

Reference Type DERIVED
PMID: 24782549 (View on PubMed)

Other Identifiers

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2007-P-001371

Identifier Type: -

Identifier Source: org_study_id