Efficacy and Safety of Telbivudine 600mg Tablets in Chinese Patients With Chronic Hepatitis B

NCT ID: NCT00781105

Last Updated: 2017-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

2200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-01

Study Completion Date

2010-09-16

Brief Summary

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The "Chinese PAC" study (CLDT600ACN03) will evaluate the efficacy and safety of open label telbivudine in 2,200 compensated Chronic Hepatitis B (CHB) adults. The primary objective of the study is the proportion of patients achieving undetectable HBV DNA at week 52.

Detailed Description

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Conditions

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Chronic Hepatitis B

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Telbivudine

Intervention Type DRUG

600 mg/day, oral tablets, once daily, 52 weeks

Interventions

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Telbivudine

600 mg/day, oral tablets, once daily, 52 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male or female 16 to 65 year of age
* Documented CHB defined by detectable serum HBsAg and serum HBV DNA level
* Willing and able to comply with the study drug regimen
* Written informed consent before any assessment

Exclusion Criteria

* Patient has a history of/or clinical signs/symptoms of hepatic decompensation
* Patient has a history of HCC or findings suggestive of possible HCC
* Patient has received treatment of nucleoside or nucleotide drugs whether approved or investigational at any time
* History of hypersensitivity to any of the drugs (telbivudine) or to drugs of similar clinical classes
* Patient has received IFN or other immunomodulatory treatment with 12 months before screening
* Previous treatment history with NRTIs
Minimum Eligible Age

16 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jia Jidong, Dr.

Role: PRINCIPAL_INVESTIGATOR

Beijing Friendship Hospital

Locations

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Novartis Investigative Site

Beijing, , China

Site Status

Countries

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China

Other Identifiers

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CLDT600ACN03

Identifier Type: -

Identifier Source: org_study_id

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