Study of the Efficacy and Safety of Quetiapine Fumarate Extended Release (Seroquel XR)

NCT ID: NCT00779506

Last Updated: 2011-11-23

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-11-30

Study Completion Date

2009-07-31

Brief Summary

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This is an 8-week, multi-centre, Open-label, non-comparative study to evaluate the efficacy and safety of Quetiapine XR with daily dose 400mg-800mg used as mono-therapy in the treatment of acute schizophrenic patients. The eligible patient will be assigned to study treatment with Quetiapine XR on Day 1.

PLEASE NOTE: Seroquel SR and Seroquel XR refer to the same formulation. The SR designation was changed to XR after consultation with FDA.

Detailed Description

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Conditions

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Schizophrenia

Keywords

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Acute schizophrenia PANSS

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Quetiapine Fumarate XR

Seroquel XR 400-800mg

Group Type EXPERIMENTAL

Quetiapine Fumarate XR

Intervention Type DRUG

oral, once daily, flexible dose

Interventions

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Quetiapine Fumarate XR

oral, once daily, flexible dose

Intervention Type DRUG

Other Intervention Names

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Seroquel XR

Eligibility Criteria

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Inclusion Criteria

* Documented clinical diagnosis meeting the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria
* PANSS total score of at least 70 at enrolment and at assignment Day 1
* CGI Severity of Illness score of at least 4 (moderately ill) at enrolment and at assignment Day 1 and with worsening of the patient's condition during the 3 weeks

Exclusion Criteria

* Known intolerance or lack of response to quetiapine fumarate
* Administration of a depot antipsychotic injection within one dosing interval (for the depot) before assignment
* Substance or alcohol dependence at enrolment
* Opiates, amphetamine, barbiturate, cocaine, cannabis, or hallucinogen abuse by DSM-IV criteria within 4 weeks prior to enrolment
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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YounHoon Kim

Role: PRINCIPAL_INVESTIGATOR

Inje University

Locations

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Research site

Ansan, Gyeonggi-do, South Korea

Site Status

Research site

Gwangju, Gyeonggi-do, South Korea

Site Status

Research site

Bugok, Gyeongsangnam-do, South Korea

Site Status

Research site

Masan, Gyeongsangnam-do, South Korea

Site Status

Research site

Incheon, , South Korea

Site Status

Research site

Pusan, , South Korea

Site Status

Research site

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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D1443L00062

Identifier Type: -

Identifier Source: org_study_id