Study to Evaluate the Inflammatory Cells Activity in Patients With Persistent Asthma Treated With Montelukast (0476-403)(COMPLETED)

NCT ID: NCT00770900

Last Updated: 2010-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

83 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-09-30

Study Completion Date

2009-12-31

Brief Summary

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Verify if the quantitative parameters of the eosinophils activation and phagocyte system function show a predictive value for clinical response and prognostic in patients with persistent asthma treated with montelukast

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Montelukast

Asthmatic children and teenagers took montelukast daily.

Group Type EXPERIMENTAL

montelukast sodium

Intervention Type DRUG

Asthmatic children and teenagers took montelukast daily for 12 weeks.

Children aged 2-5 years took 4mg tablet of montelukast

Children aged 6-15 years took 5mg tablet of montelukast

Children \>15 years took 10mg tablet of montelukast

Placebo

Placebo to montelukast tablet daily.

Group Type PLACEBO_COMPARATOR

Comparator: placebo comparator

Intervention Type DRUG

Asthmatic children and teenagers took Placebo tablet daily for 12 weeks.

Interventions

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montelukast sodium

Asthmatic children and teenagers took montelukast daily for 12 weeks.

Children aged 2-5 years took 4mg tablet of montelukast

Children aged 6-15 years took 5mg tablet of montelukast

Children \>15 years took 10mg tablet of montelukast

Intervention Type DRUG

Comparator: placebo comparator

Asthmatic children and teenagers took Placebo tablet daily for 12 weeks.

Intervention Type DRUG

Other Intervention Names

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Singulair

Eligibility Criteria

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Inclusion Criteria

Patients Between 2-18 Years With Persistent Asthma

Exclusion Criteria

Patients \> 18 Years Old And \< 2 Years Old
Minimum Eligible Age

2 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Brasilia

OTHER

Sponsor Role lead

Responsible Party

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Merck Sharp & Dohme Corp

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Countries

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Brazil

Other Identifiers

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MK0476-403

Identifier Type: -

Identifier Source: secondary_id

2008_563

Identifier Type: -

Identifier Source: org_study_id