Trial Outcomes & Findings for The Effect of Intravenous Anesthetics on Fear Learning and Memory (NCT NCT00767767)

Results Overview

Galvanic skin repose (GSR) to the first habituation trial (yes/no). Coding: Yes (0) and No (1)

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

67 participants

Primary outcome timeframe

First Trial, for up to 1 day

Results posted on

2019-05-15

Participant milestones
Measure	Placebos Saline Infusion Placebos: IV Saline infusion for 2 hours.	Propofol 0.45mcg/mL Anesthetic Drug Infusion Propofol 0.45mcg/mL: IV Propofol infusion for 2 hours.	Propofol 0.9mcg/mL Anesthetic Drug Infusion Propofol 0.9mcg/mL: IV Propofol infusion for 2 hours.	Thiopental 1.5mcg/mL Anesthetic Drug Infusion Thiopental 1.5mcg/mL: IV Thiopental infusion for 2 hours.	Thiopental 3mcg/mL Anesthetic Drug Infusion Thiopental 3mcg/mL: IV Thiopental Infusion for 2 hours.
Overall Study STARTED	21	20	20	3	3
Overall Study COMPLETED	21	20	20	3	3
Overall Study NOT COMPLETED	0	0	0	0	0

Withdrawal data not reported

The Effect of Intravenous Anesthetics on Fear Learning and Memory

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Placebos n=21 Participants Saline Infusion Placebos: IV Saline infusion for 2 hours.	Propofol 0.45mcg/mL n=20 Participants Anesthetic Drug Infusion Propofol 0.45mcg/mL: IV Propofol infusion for 2 hours.	Propofol 0.9mcg/mL n=20 Participants Anesthetic Drug Infusion Propofol 0.9mcg/mL: IV Propfol infusion for 2 hours.	Thiopental 1.5mcg/mL n=3 Participants Anesthetic Drug Infusion Thiopental 1.5mcg/mL: IV Thiopental infusion for 2 hours.	Thiopental 3mcg/mL n=3 Participants Anesthetic Drug Infusion Thiopental 3mcg/mL: IV Thiopental Infusion for 2 hours.	Total n=67 Participants Total of all reporting groups
Age, Continuous	25.1 years STANDARD_DEVIATION 4.4 • n=5 Participants	25.4 years STANDARD_DEVIATION 4.1 • n=7 Participants	25.6 years STANDARD_DEVIATION 4.5 • n=5 Participants	23.7 years STANDARD_DEVIATION 3.4 • n=4 Participants	26.3 years STANDARD_DEVIATION 5.8 • n=21 Participants	25.2 years STANDARD_DEVIATION 4.4 • n=8 Participants
Sex: Female, Male Female	14 Participants n=5 Participants	10 Participants n=7 Participants	16 Participants n=5 Participants	2 Participants n=4 Participants	0 Participants n=21 Participants	42 Participants n=8 Participants
Sex: Female, Male Male	7 Participants n=5 Participants	10 Participants n=7 Participants	4 Participants n=5 Participants	1 Participants n=4 Participants	3 Participants n=21 Participants	25 Participants n=8 Participants

Timeframe: First Trial, for up to 1 day

Galvanic skin repose (GSR) to the first habituation trial (yes/no). Coding: Yes (0) and No (1)