Evaluation of Wound Biofilm in Acute and Chronic Wounds

NCT ID: NCT00764348

Last Updated: 2011-09-07

Basic Information

• Recruitment Status: WITHDRAWN
• Study Classification: OBSERVATIONAL

Brief Summary

Patients who present to a wound care center for management of their wounds will be evaluated clinically to establish if their wounds are chronic or acute. These patients will undergo standard of care management of their wounds. If debridement is indicated for the patient, the patient will be asked to participate in a study. Once the standard of care debridement is complete, the material debrided from the wound, instead of being discarded into a biohazard bag, will be prepared for shipment. The samples will then be shipped to the Center for Biofilm Engineering where microscopic evaluation will be conducted on the material. Conclusion will be made from that analysis.

Detailed Description

A planktonic concept of the bacteria present on the surface of a chronic wound is no longer viable. Microscopic studies show that biofilm is present on chronic wounds yet does not seem to be prominent on the surface of acute wounds. Biofilm is able to neutralize our host defenses and commandeer host systems, and possesses an impressive array of defenses and virulence factors. Clinically we see a significant difference in the healing behavior between chronic and acute wounds. Also, suppression of biofilm using multiple simultaneous strategies including debridement, anti-biofilm agents, specific biocides, antibiotics and advanced technologies improves wound healing. This suggests biofilm plays an important role in delayed wound healing.

Conditions

Wounds

Study Design

• Study Time Perspective: PROSPECTIVE

Study Groups

no treatment

no treatment

Intervention Type: OTHER

Interventions

no treatment

Intervention Type: OTHER

Eligibility Criteria

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Southwest Regional Wound Care Center

OTHER

Sponsor Role: lead

Responsible Party

Randall Wolcott

Prinicipal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

56-RW-002

Identifier Type: -

Identifier Source: org_study_id