Radioiodine Dosimetry Protocol for Thyroid Cancer Metastases

NCT ID: NCT00749697

Last Updated: 2008-09-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-05-31

Study Completion Date

2010-07-31

Brief Summary

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The main purpose of the study is to establish a relationship between the administered activity of the radioiodine and absorbed dose in the tumor sites.

Detailed Description

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Study Design - the assessment of patients with multiple tumour sites with metastatic thyroid cancer to correlate the administered activity to absorbed dose. Patients will receive the standard therapy dose of 5.5 GBq as per the hospital policy and there will be no change for the protocol purpose.

Conditions

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Thyroid Carcinoma Metastatic Sites Lung Bone Nodal

Keywords

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radioiodine differentiated thyroid cancers dosimetry metastases

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Interventions

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SPECT scan

SPECT scan measures the amount of radio activity that is remaining in patients' body after the consumption of radio iodine for therapeutic purpose

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age above 18
* histological confirmation of the differentiated thyroid carcinoma available
* WHO performance score 0-2
* metastatic sites lung and/or bone and/or nodal (radiologically measurable disease \> 1 cm)
* life expectancy \> 6 months
* patient has undergone total/near total thyroidectomy
* no past history of sensitivity/reaction to 1311

Exclusion Criteria

* non iodine concentrating tumours
* received chemotherapy or radiotherapy in 6 weeks
* pregnant or breast feeding patients
* iodine contrast injection in last 3 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Royal Marsden NHS Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Royal Marsden NHS Foundation Trust

Principal Investigators

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Dr Kate Newbold

Role: PRINCIPAL_INVESTIGATOR

Royal Marsden NHS Foundation Trust

Locations

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Royal Marsden NHS Foundation Trust

London, Sutton, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Dr Kate Newbold

Role: CONTACT

Phone: 020 86613638

Email: [email protected]

Dr Prasad Dandekar

Role: CONTACT

Phone: 020 8661 3454

Email: [email protected]

Facility Contacts

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Dr Kate Newbold

Role: primary

Dr Prasad Dandekar

Role: backup

Other Identifiers

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CCR3047

Identifier Type: -

Identifier Source: org_study_id