Prospective Comparison of Immunological Benefit of Laparoscopic Colectomy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-01-31

Study Completion Date

2007-11-30

Brief Summary

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This study aimed to clarify existence of immunological benefit of laparoscopic colon cancer surgery compared to open colon surgery.

Detailed Description

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Patients with clinical stage Ⅲ left colon and upper rectal cancer were prospectively assigned to undergo LC (n=35) or OC (n=39). Factors related to cellular immunity of host (total lymphocyte count, CD4 lymphocyte, CD8 lymphocyte, CD4/CD8 ratio, HLA-DR expression on monocyte (mHLA-DR)) were examined preoperatively, on the 1st day of operation (POD1) and the 5th day of operation (POD5).

Conditions

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Immunity

Keywords

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colon cancer laparoscopic colorectal surgery cellular immunity HLA-DR expression on monocyte

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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OC

Open colorectal resection

No interventions assigned to this group

LC

Laparoscopic colorectal resection

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Biopsy proven of colon cancer
* Preoperatively suspected as clinical stage III colon cancer
* Lesion located Descending colon, sigmoid colon and upper rectal cancer

Exclusion Criteria

* Could not perform curative resection
* Intestinal obstruction, perforation, intra-abdominal abscess
* Severe medical illness
* Immunopathy

Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Samsugn Medical Center

Principal Investigators

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Woo Yong Lee, MD,PhD

Role: STUDY_CHAIR

Samsung Medical Center

Locations

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Samsung Medical Center, Department of surgery

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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#CRS-106-14-1

Identifier Type: -

Identifier Source: secondary_id

IRB 2005-08-041