Presep and Vascath Interaction Study

NCT ID: NCT00739089

Last Updated: 2017-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2008-08-31

Study Completion Date

2009-12-31

Brief Summary

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This is a prospective, observational study to compare presep(tm) catheter central vein mixed venous oxygen saturation before and after dialysis is initiated via the vascath(tm) central venous dialysis catheter to evaluate device interaction.

Detailed Description

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The central venous oxygen saturation catheter measurement may be influenced by close approximation to the tip of the central venous hemodialysis catheter when hemodialysis is ongoing.

Conditions

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Hemodynamics Renal Dialysis Sepsis Shock

Keywords

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hemodynamics oxygen renal dialysis shock sepsis hypotension lactic acidosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Admitted to the MICU
* PreSep venous oxygen saturation central venous catheter already in place
* VasCath central venous dialysis catheter already in place
* Planned hemodialysis

Exclusion Criteria

* Patient unable to undergo hemodialysis
* Contraindication for PreSep or VasCath catheters
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wake Forest University Health Sciences

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Arjun B Chatterjee, MD, MS

Role: PRINCIPAL_INVESTIGATOR

Wake Forest University Health Sciences

Locations

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Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Site Status

Countries

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United States

References

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Vaziri ND, Wilson A, Mukai D, Darwish R, Rutz A, Hyatt J, Moreno C. Dialysis hypoxemia. Role of dialyzer membrane and dialysate delivery system. Am J Med. 1984 Nov;77(5):828-33. doi: 10.1016/0002-9343(84)90519-9.

Reference Type BACKGROUND
PMID: 6496536 (View on PubMed)

Jakob SM, Ruokonen E, Vuolteenaho O, Lampainen E, Takala J. Splanchnic perfusion during hemodialysis: evidence for marginal tissue perfusion. Crit Care Med. 2001 Jul;29(7):1393-8. doi: 10.1097/00003246-200107000-00015.

Reference Type BACKGROUND
PMID: 11445693 (View on PubMed)

Krafft P, Steltzer H, Hiesmayr M, Klimscha W, Hammerle AF. Mixed venous oxygen saturation in critically ill septic shock patients. The role of defined events. Chest. 1993 Mar;103(3):900-6. doi: 10.1378/chest.103.3.900.

Reference Type BACKGROUND
PMID: 8449089 (View on PubMed)

De Backer WA, Verpooten GA, Borgonjon DJ, Vermeire PA, Lins RR, De Broe ME. Hypoxemia during hemodialysis: effects of different membranes and dialysate compositions. Kidney Int. 1983 May;23(5):738-43. doi: 10.1038/ki.1983.87. No abstract available.

Reference Type BACKGROUND
PMID: 6876569 (View on PubMed)

Quebbeman EJ, Maierhofer WJ, Piering WF. Mechanisms producing hypoxemia during hemodialysis. Crit Care Med. 1984 Apr;12(4):359-63. doi: 10.1097/00003246-198404000-00004.

Reference Type BACKGROUND
PMID: 6705543 (View on PubMed)

Murray P, Hall J. Renal replacement therapy for acute renal failure. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):777-81. doi: 10.1164/ajrccm.162.3.ncc400. No abstract available.

Reference Type BACKGROUND
PMID: 10988080 (View on PubMed)

Other Identifiers

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IRB00004073

Identifier Type: -

Identifier Source: org_study_id