Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department

NCT ID: NCT00738816

Last Updated: 2010-12-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

108 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-04-30

Study Completion Date

2010-04-30

Brief Summary

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Elderly patients have a higher risk of experiencing adverse drug events due to an age related increase in morbidity and medication use. Inappropriate or wrong medication use among elderly patients acutely admitted to hospitals is assumed to result in earlier contact to general practitioner, emergency departments and re-admissions if not corrected during hospital admission. It is therefore our hypothesis that a systematic medication review conducted by pharmacists and physicians specialized in pharmacology will increase time to first unscheduled physician contact (general practitioner, emergency departments, ambulatory care and re-admissions) after discharge from hospital from an average of 21days to 25 days. Further, the following secondary outcome parameters will be measured at discharge and within 3-month follow-up:

* length of in-hospital stay
* number of contacts to general practitioner 30 days after discharge, that resulted in medication changes
* number of re-admissions at 3-month
* number of death at 3-month
* number of contact to primary health care at 3-month
* patients self-experienced quality of health(EQ-5D) 3-month

Detailed Description

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Conditions

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Elderly

Keywords

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Medication review Patient Safety Drug Prescriptions Drug-use

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Intervention

Systematic medication review

Group Type OTHER

Systematic medication review and advisory notes

Intervention Type OTHER

Within 24 hours of admission a pharmacist retrieve medication histories from patients included in the intervention group. Medication histories will be obtained from - medical records, medication charts, patients electronical medication profile, interview with patients and if necessary contact to the patients general practitioner. The obtained medication history will be discussed with a physician specialized in pharmacology and an advisory note with suggested changes to the patients medication is added to the medical record. The orthopedic physicians are not obliged to follow the suggested changes

Interventions

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Systematic medication review and advisory notes

Within 24 hours of admission a pharmacist retrieve medication histories from patients included in the intervention group. Medication histories will be obtained from - medical records, medication charts, patients electronical medication profile, interview with patients and if necessary contact to the patients general practitioner. The obtained medication history will be discussed with a physician specialized in pharmacology and an advisory note with suggested changes to the patients medication is added to the medical record. The orthopedic physicians are not obliged to follow the suggested changes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* age 65 years or older
* expected admission time of more than 24 hours
* acute admission

Exclusion Criteria

* Psychotic patients
* Moribund patients
* Suicidal patients
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aarhus University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Aarhus University Hospital

Principal Investigators

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Nielsen Lars Peter, Assoc. Prof.

Role: PRINCIPAL_INVESTIGATOR

Aarhus University Hospital, Denmark

Locations

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Regional hospital, Randers

Randers, Central Jutland, Denmark

Site Status

Countries

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Denmark

References

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Holland R, Desborough J, Goodyer L, Hall S, Wright D, Loke YK. Does pharmacist-led medication review help to reduce hospital admissions and deaths in older people? A systematic review and meta-analysis. Br J Clin Pharmacol. 2008 Mar;65(3):303-16. doi: 10.1111/j.1365-2125.2007.03071.x. Epub 2007 Dec 17.

Reference Type BACKGROUND
PMID: 18093253 (View on PubMed)

Lau HS, Florax C, Porsius AJ, De Boer A. The completeness of medication histories in hospital medical records of patients admitted to general internal medicine wards. Br J Clin Pharmacol. 2000 Jun;49(6):597-603. doi: 10.1046/j.1365-2125.2000.00204.x.

Reference Type BACKGROUND
PMID: 10848724 (View on PubMed)

Glintborg B, Andersen SE, Dalhoff K. Drug-drug interactions among recently hospitalised patients--frequent but mostly clinically insignificant. Eur J Clin Pharmacol. 2005 Oct;61(9):675-81. doi: 10.1007/s00228-005-0978-6. Epub 2005 Oct 19.

Reference Type BACKGROUND
PMID: 16047138 (View on PubMed)

Page RL 2nd, Ruscin JM. The risk of adverse drug events and hospital-related morbidity and mortality among older adults with potentially inappropriate medication use. Am J Geriatr Pharmacother. 2006 Dec;4(4):297-305. doi: 10.1016/j.amjopharm.2006.12.008.

Reference Type BACKGROUND
PMID: 17296535 (View on PubMed)

Vira T, Colquhoun M, Etchells E. Reconcilable differences: correcting medication errors at hospital admission and discharge. Qual Saf Health Care. 2006 Apr;15(2):122-6. doi: 10.1136/qshc.2005.015347.

Reference Type BACKGROUND
PMID: 16585113 (View on PubMed)

Other Identifiers

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Klinfarm

Identifier Type: -

Identifier Source: org_study_id