An Investigation Of The Effects Of Food On The Absorption Of A Varenicline Controlled Release Formulation

NCT ID: NCT00731562

Last Updated: 2010-01-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2008-09-30

Brief Summary

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1. To estimate the absorption of a single oral dose of a controlled release varenicline tablet under fed and fasted conditions.
2. To evaluate the pharmacokinetics, safety, and tolerability of a single dose of a varenicline controlled release tablet under fed and fasted conditions.

Detailed Description

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Conditions

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Pharmacokinetics Bioavailability Smoking Cessation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

NONE

Study Groups

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Varenicline Controlled Release, Fasted

Group Type EXPERIMENTAL

Varenicline Tartrate Controlled Release

Intervention Type DRUG

A single, 2.4 mg dose of a varenicline controlled release tablet administered orally under fasted conditions

Varenicline Controlled Release, Fed

Group Type EXPERIMENTAL

Varenicline Tartrate Controlled Release

Intervention Type DRUG

A single, 2.4 mg dose of a varenicline controlled release tablet administered orally under fed conditions

Interventions

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Varenicline Tartrate Controlled Release

A single, 2.4 mg dose of a varenicline controlled release tablet administered orally under fasted conditions

Intervention Type DRUG

Varenicline Tartrate Controlled Release

A single, 2.4 mg dose of a varenicline controlled release tablet administered orally under fed conditions

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy male or female adult smokers
* 18 to 55 years of age

Exclusion Criteria

* Sensitivity to varenicline
* Illegal drug use
* Pregnant or nursing females
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Pfizer, Inc.

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

East Grand Forks, Minnesota, United States

Site Status

Pfizer Investigational Site

Fargo, North Dakota, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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A3051088

Identifier Type: -

Identifier Source: org_study_id

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