Pharmacokinetic Study for PCA Derivate Formulations

NCT ID: NCT00729729

Last Updated: 2012-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-07-31

Study Completion Date

2009-12-31

Brief Summary

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A comparative bioavailability study of PCA slow release versus immediate release formulations, after a single dose to fasting healthy subjects.

Detailed Description

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Conditions

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Healthy

Keywords

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Comparative bioavailability of PCA formulations

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Placebo

Group Type PLACEBO_COMPARATOR

PCA

Intervention Type DRUG

Placebo tablet, once

2

Slow release PCA derivative

Group Type EXPERIMENTAL

PCA

Intervention Type DRUG

PO, 700mg, once

3

Slow release PCA derivative higher dose

Group Type EXPERIMENTAL

PCA

Intervention Type DRUG

PO, 1000mg, once

Interventions

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PCA

Placebo tablet, once

Intervention Type DRUG

PCA

PO, 700mg, once

Intervention Type DRUG

PCA

PO, 1000mg, once

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Subjects who have completed the informed consent process culminating with written informed consent by the subject.
* Males
* Age 18-45 years
* Abstinence from alcohol for 1 week prior to the study
* Non smoking
* BMI \> 19 and \< 30
* No history or evidence of significant

* cardiovascular,
* hepatic,
* renal,
* hematopoietic,
* gastrointestinal disease,
* endocrine,
* metabolic,
* psychiatric
* psychological disorders
* Normal physical examination
* Within +/- 10% of normal values in laboratory examinations

Exclusion Criteria

* Subjects who suffer from a current medical condition.
* Subjects who smoke.
* Subjects who drink \> 20 grams of alcohol per day.
* Subjects who take prescription medication.
* Subjects with an abnormality in screening blood tests
* Known sensitivity to any ingredients in the study drug
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Hadassah Medical Organization

OTHER

Sponsor Role lead

Responsible Party

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Hadassah Medical Organization

Locations

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Hadassah Medical Organization

Jerusalem, , Israel

Site Status

Countries

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Israel

Other Identifiers

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PCA pharmacokinetics 1

Identifier Type: -

Identifier Source: org_study_id