Treatment of Acetaminophen Toxicity With N-acetylcysteine
NCT ID: NCT00725179
Last Updated: 2011-09-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
130 participants
OBSERVATIONAL
2008-08-31
2008-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Study Groups
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1
Patients receiving oral NAC treatment
No interventions assigned to this group
2
Patients receiving IV NAC treatment
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Serum APAP concentrations ≥ 150 g/mL at 4 hours or a serum concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained \> 4 hours post ingestion
* Between the ages of 0-21 years
Exclusion Criteria
* Patient did not receive oral or IV NAC treatment
* Patient has a preexisting liver disease such as cirrhosis or hepatitis C
* Patient \> 21 years of age
ALL
No
Sponsors
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Akron Children's Hospital
OTHER
Responsible Party
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Martha Blackford
PharmD
Principal Investigators
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Martha Blackford, PharmD
Role: PRINCIPAL_INVESTIGATOR
CHMCA
Locations
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Children's Hospital Medical Center of Akron
Akron, Ohio, United States
Countries
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References
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Heard KJ. Acetylcysteine for acetaminophen poisoning. N Engl J Med. 2008 Jul 17;359(3):285-92. doi: 10.1056/NEJMct0708278.
Culley CM, Krenzelok EP. A clinical and pharmacoeconomic justification for intravenous acetylcysteine: a US perspective. Toxicol Rev. 2005;24(2):131-43. doi: 10.2165/00139709-200524020-00007.
Kanter MZ. Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. Am J Health Syst Pharm. 2006 Oct 1;63(19):1821-7. doi: 10.2146/ajhp060050.
Blackford MG, Felter T, Gothard MD, Reed MD. Assessment of the clinical use of intravenous and oral N-acetylcysteine in the treatment of acute acetaminophen poisoning in children: a retrospective review. Clin Ther. 2011 Sep;33(9):1322-30. doi: 10.1016/j.clinthera.2011.08.005. Epub 2011 Sep 3.
Other Identifiers
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APAP & NAC
Identifier Type: -
Identifier Source: org_study_id
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