Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Who Have Received First-Line Chemotherapy and Bevacizumab

NCT ID: NCT00720512

Last Updated: 2015-03-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE3
• Total Enrollment: 184 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-06-30
• Study Completion Date: 2014-03-31

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as irinotecan, oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether combination chemotherapy is more effective with or without bevacizumab in treating metastatic colorectal cancer.

PURPOSE: This randomized phase III trial is studying second-line combination chemotherapy to see how well it works compared with or without bevacizumab in treating patients with metastatic colorectal cancer who have received first-line chemotherapy and bevacizumab.

Detailed Description

OBJECTIVES:

Primary

• To compare the progression-free survival of second-line chemotherapy with or without bevacizumab in patients with metastatic colorectal cancer who have received first-line chemotherapy with bevacizumab.

Secondary

• To compare the overall survival, response rate, and safety profile of second-line chemotherapy of these regimens in these patients.
• To conduct pharmacogenomics assessment of candidate variants in the VEGF gene and evaluate their association with progression-free survival and other study outcomes.

OUTLINE: This is a multicenter study. Patients are stratified according to participating center, ECOG performance status (0 vs 1-2), disease-free interval from the last administration of first-line chemotherapy for metastatic disease (≤ 3 months vs > 3 months), and type of second-line chemotherapy (irinotecan hydrochloride, leucovorin calcium, and fluorouracil [FOLFIRI] vs oxaliplatin, leucovorin calcium, and fluorouracil [mFOLFOX-6]). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive either irinotecan hydrochloride over 1 hour or oxaliplatin over 1 hour on day 1. Patients also receive leucovorin calcium IV over 2 hours and fluorouracil IV over 46 hours continuously beginning on day 1.
• Arm II: Patients receive combination chemotherapy as in arm I and bevacizumab IV on day 1.

Treatment in both arms repeats every 2 weeks for up to 12 courses in the absence of disease progression or unacceptable toxicity.

Existing formalin-fixed paraffin-embedded tumor tissue samples are assessed for pharmacogenomics and markers predictive of response, resistance to, or toxicity from bevacizumab. Samples are analyzed via RT-PCR, array comparative genomic hybridization, fluorescence in situ hybridization, sequencing of candidate genes, and immunohistochemistry.

After completion of study treatment, patients are followed for 1 year.

Conditions

Colorectal Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Arm I

Patients receive either irinotecan hydrochloride over 1 hour or oxaliplatin over 1 hour on day 1. Patients also receive leucovorin calcium IV over 2 hours and fluorouracil IV over 46 hours continuously beginning on day 1. Treatment repeats every 2 weeks for up to 12 courses in the absence of disease progression or unacceptable toxicity.

Group Type: ACTIVE_COMPARATOR

fluorouracil

Intervention Type: DRUG

Given IV

irinotecan hydrochloride

Intervention Type: DRUG

Given IV

leucovorin calcium

Intervention Type: DRUG

Given IV

oxaliplatin

Intervention Type: DRUG

Given IV

Arm II

Patients receive combination chemotherapy as in arm I and bevacizumab IV on day 1. Treatment repeats every 2 weeks for up to 12 courses in the absence of disease progression or unacceptable toxicity.

Group Type: EXPERIMENTAL

bevacizumab

Intervention Type: BIOLOGICAL

Given IV

fluorouracil

Intervention Type: DRUG

Given IV

irinotecan hydrochloride

Intervention Type: DRUG

Given IV

leucovorin calcium

Intervention Type: DRUG

Given IV

oxaliplatin

Intervention Type: DRUG

Given IV

Interventions

bevacizumab

Given IV

Intervention Type: BIOLOGICAL

fluorouracil

Given IV

Intervention Type: DRUG

irinotecan hydrochloride

Given IV

Intervention Type: DRUG

leucovorin calcium

Given IV

Intervention Type: DRUG

oxaliplatin

Given IV

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed colorectal adenocarcinoma

• Metastatic or unresectable disease
• Progressive disease based on the following criteria:

• Progression during or after first-line chemotherapy for metastatic disease, including any of the following:

• Fluoropyrimidine-based monotherapy with bevacizumab
• Fluoropyrimidine and irinotecan hydrochloride-based doublet with bevacizumab
• Fluoropyrimidine and oxaliplatin-based doublet with bevacizumab
• Progression after more than 3 months from the last administration of first-line chemotherapy for metastatic disease with a fluoropyrimidine, irinotecan hydrochloride, and oxaliplatin triplet (FOLFOXIRI) with bevacizumab to which the patient had previously responded
• Measurable disease, as assessed by RECIST criteria
• No prior or concurrent CNS metastasis

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2
• Life expectancy > 3 months
• ANC ≥ 1,500/mm^3
• Platelet count ≥ 100,000/mm^3
• Hemoglobin ≥ 9 g/dL
• INR ≤ 1.5 times upper limit of normal (ULN)
• aPTT ≤ 1.5 ULN
• Serum bilirubin ≤ 1.5 times ULN
• AST and ALT ≤ 2.5 times ULN (< 5 times ULN if liver metastases present)
• Alkaline phosphatase ≤ 2.5 times ULN (< 5 times ULN if liver metastases present)
• Serum creatinine ≤ 1.5 times ULN
• Proteinuria < 2+ OR protein ≤ 1g by 24-hour urine
• Not pregnant or nursing
• Fertile patients must use effective contraception
• No bowel obstruction or subobstruction
• No history of inflammatory enteropathy
• No prior extensive intestinal resection (i.e., > hemicolectomy or extensive small intestine resection with chronic diarrhea)
• No symptomatic peripheral neuropathy > grade 2
• No active uncontrolled infection
• No active disseminated intravascular coagulation
• No prior or concurrent malignancy, except for curatively treated basal cell and squamous cell carcinoma of the skin, or in situ carcinoma of the cervix
• No clinically significant cardiovascular disease, including any of the following:

• Cerebrovascular accident within the past 6 months
• Myocardial infarction within the past 6 months
• Unstable angina
• NYHA class II-IV chronic heart failure
• Uncontrolled arrhythmia
• No uncontrolled hypertension
• No thromboembolic or hemorrhagic events within the past 6 months
• No evidence of bleeding diathesis or coagulopathy
• No serious, non healing wound/ulcer or serious bone fracture
• No significant traumatic injury within the past 28 days

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• At least 6 weeks since prior radiotherapy
• At least 4 weeks since prior surgery
• No prior first-line chemotherapy for metastatic disease without bevacizumab
• No prior cetuximab or other investigational agents
• More than 28 days since prior open biopsy
• More than 28 days since prior and no concurrent major surgical procedure
• No concurrent therapeutic anticoagulation, antiplatelet agents, or NSAID with anti-platelet activity

• Acetylsalicylic acid ≤ 325 mg/day allowed

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Gruppo Oncologico del Nord-Ovest

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Alfredo Falcone, MD

Role: PRINCIPAL_INVESTIGATOR

Presidio Ospedaliero di Livorno

Locations

Universita Politecnica Delle Marche

Ancona, , Italy

Azienda Usl 8 Arezzo

Arezzo, , Italy

Ospedale degli Infermi - ASL 12

Biella, , Italy

A. Perrino Hospital

Brindisi, , Italy

Azienda Ospedaliera S. Elia

Caltanissetta, , Italy

Ospedale Santa Croce

Cuneo, , Italy

Ospedale San Giuseppe

Empoli, , Italy

Ospedale E. Profili

Fabriano, , Italy

Ospedale Civile S. Croce

Fano, , Italy

Azienda Ospedaliera di Firenze

Florence, , Italy

Azienda Ospedaliero Careggi

Florence, , Italy

Istituto Nazionale per la Ricerca sul Cancro

Genoa, , Italy

Ospendale S. Andrea EST

La Spezia, , Italy

Azienda Ospedaliera Vito Fazzi

Lecce, , Italy

Azienda USL12 Versilia

Lido di Camaiore, , Italy

Ospedale Campo Di Marte Lucca

Lucca, , Italy

Azienda Ospedaliera Maggiore Della Carita

Novara, , Italy

Azienda Ospedaliera Pisana

Pisa, , Italy

Arcispedale S. Maria Nuova

Reggio Emilia, , Italy

Azienda Ospedaliera Universitaria Senese

Siena, , Italy

Dipartimento Oncologico

Siena, , Italy

Countries

Italy

References

Masi G, Salvatore L, Boni L, Loupakis F, Cremolini C, Fornaro L, Schirripa M, Cupini S, Barbara C, Safina V, Granetto C, Fea E, Antonuzzo L, Boni C, Allegrini G, Chiara S, Amoroso D, Bonetti A, Falcone A; BEBYP Study Investigators. Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: final results of the randomized BEBYP trial. Ann Oncol. 2015 Apr;26(4):724-730. doi: 10.1093/annonc/mdv012. Epub 2015 Jan 18.

Reference Type: DERIVED

PMID: 25600568 (View on PubMed)

Other Identifiers

GONO-BEBYP-ASL607LIOM03

Identifier Type: -

Identifier Source: secondary_id

GONO-AIFA - FARM5C4FB4

Identifier Type: -

Identifier Source: secondary_id

EUDRACT:2007-002886-11

Identifier Type: -

Identifier Source: secondary_id

CDR0000598567

Identifier Type: -

Identifier Source: org_study_id