Pilot Study of Green Tea Extract (Polyphenon E®)in Ulcerative Colitis

NCT ID: NCT00718094

Last Updated: 2017-12-14

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-03-31

Study Completion Date

2012-04-30

Brief Summary

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Green tea consists of several components, with most research focusing on the polyphenol fraction. The polyphenol fraction(-)-epigallocatechin-3-gallate (EGCG)has been studied extensively as an anti-inflammatory agent as well as a preventative agent for cancer. It has been shown to effectively reduce the inflammation associated with animal models of inflammatory bowel disease. This clinical trial will determine the ability of EGCG, in the form of Polyphenon E®, to treat patients with mild to moderately severe ulcerative colitis.

Detailed Description

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Conditions

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Mild to Moderately Active Ulcerative Colitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Polyphenon E treatment

Polyphenon E® therapy was given for 56 days.

Group Type EXPERIMENTAL

Polyphenon E®

Intervention Type DRUG

Oral capsules

Placebo

Oral Placebo

Group Type PLACEBO_COMPARATOR

Placebo Oral Tablet

Intervention Type DRUG

Oral tablet: placebo

Interventions

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Polyphenon E®

Oral capsules

Intervention Type DRUG

Placebo Oral Tablet

Oral tablet: placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult male or female with mildly to moderately active ulcerative colitis

Exclusion Criteria

* Off prohibited medications for proscribed period of time
* Evidence of infectious colitis
* Labs outside of range
* Pregnancy or lactation
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

University of Louisville

OTHER

Sponsor Role lead

Responsible Party

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Gerald W. Dryden, Jr.

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gerald W Dryden, MD, MSPH

Role: PRINCIPAL_INVESTIGATOR

University of Louisville

Locations

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University of Louisville Clinical Research Center

Louisville, Kentucky, United States

Site Status

Countries

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United States

References

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Dryden GW, Lam A, Beatty K, Qazzaz HH, McClain CJ. A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis. Inflamm Bowel Dis. 2013 Aug;19(9):1904-12. doi: 10.1097/MIB.0b013e31828f5198.

Reference Type RESULT
PMID: 23846486 (View on PubMed)

Other Identifiers

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5K23DK073750

Identifier Type: NIH

Identifier Source: secondary_id

View Link

390.05

Identifier Type: -

Identifier Source: org_study_id

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