Observational Patient Diary Study of Treatment Doses for Patients With Haemophilia With Inhibitors to Factors VIII and IX

NCT ID: NCT00710619

Last Updated: 2016-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

52 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-06-30

Study Completion Date

2009-07-31

Brief Summary

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This study is conducted in the United States of America (USA). The aim of this study is to investigate the at-home-administration of bypassing agents for treatment of bleeding episodes in patients with congenital haemophilia with inhibitors to factors VIII and IX. We are further investigating how bleeding episodes affect the quality of life of the patient and their family or caregivers.

Detailed Description

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Conditions

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Congenital Bleeding Disorder Haemophilia A With Inhibitors Haemophilia B With Inhibitors

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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A

activated recombinant human factor VII

Intervention Type DRUG

This is an observation of how patients/caregivers dose bypassing agents at home for haemophilia with inhibitors

Feiba VH

Intervention Type DRUG

This is an observation of how patients/caregivers dose bypassing agents at home for hemophilia with inhibitors

Interventions

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activated recombinant human factor VII

This is an observation of how patients/caregivers dose bypassing agents at home for haemophilia with inhibitors

Intervention Type DRUG

Feiba VH

This is an observation of how patients/caregivers dose bypassing agents at home for hemophilia with inhibitors

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male subjects with congenital haemophilia A or B and inhibitors with spontaneous bleeds which require on-demand treatment
* Subjects prescribed NovoSeven® as the first line or recommended bypass agent
* History of on average at least 4 bleeds of any type over a 3 month period
* Subject or caregiver able and willing to complete daily journal for 3 months
* Informed consent obtained from all subjects or legal representative
Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Novo Nordisk A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Global Clinical Registry (GCR, 1452)

Role: STUDY_DIRECTOR

Novo Nordisk A/S

Locations

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Novo Nordisk Investigational Site

Plainsboro, New Jersey, United States

Site Status

Countries

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United States

References

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Gruppo RA, Kessler CM, Neufeld EJ, Cooper DL. Assessment of individual dose utilization vs. physician prescribing recommendations for recombinant activated factor VII (rFVIIa) in paediatric and adult patients with congenital haemophilia and alloantibody inhibitors (CHwI): the Dosing Observational Study in Hemophilia (DOSE). Haemophilia. 2013 Jul;19(4):524-32. doi: 10.1111/hae.12113. Epub 2013 Apr 1.

Reference Type DERIVED
PMID: 23551918 (View on PubMed)

Related Links

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http://novonordisk-trials.com

Clinical Trials at Novo Nordisk

Other Identifiers

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F7HAEM-1965

Identifier Type: -

Identifier Source: org_study_id