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Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients

NCT ID: NCT00685867

Last Updated: 2012-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

126750 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-05-31

Study Completion Date

2010-12-31

Brief Summary

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The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level. A total of ten adult surgical departments with at least 3 surgical subspecialties each will participate in the study. Sites of the study are located in 9 countries (UK, France, Spain, Germany, Switzerland, Italy, Serbia, Greece and Israel).

The primary objective is to determine the effect of an early MRSA detection \& decolonization \& isolation strategy compared to an enhanced standard control strategy on healthcare-associated MRSA isolation rates among surgical patients at risk of MRSA carriage, who are hospitalized for at least 24 hours.

Detailed Description

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Conditions

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MRSA Infection

Keywords

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Staphylococcus aureus Resistance Prevention

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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1

Rapid detection

Group Type EXPERIMENTAL

Rapid molecular MRSA test

Intervention Type OTHER

PCR-based rapid screening for MRSA carriage

2

Enhanced infection control

Group Type OTHER

Hand hygiene promotion

Intervention Type BEHAVIORAL

* Promotion and monitoring of hand hygiene, with special emphasis on alcohol-based hand rubs and feedback of hand hygiene compliance
* Standard precautions (e.g. use of gloves for contacts with wounds and body fluids)
* Isolation precautions according to the hospitals' capacity and strategy
* Additional basic infection control interventions (if necessary)

Interventions

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Rapid molecular MRSA test

PCR-based rapid screening for MRSA carriage

Intervention Type OTHER

Hand hygiene promotion

* Promotion and monitoring of hand hygiene, with special emphasis on alcohol-based hand rubs and feedback of hand hygiene compliance
* Standard precautions (e.g. use of gloves for contacts with wounds and body fluids)
* Isolation precautions according to the hospitals' capacity and strategy
* Additional basic infection control interventions (if necessary)

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Surgical patients with LOS\>24h

Exclusion Criteria

* Surgical patients with LOS\<24h
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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European Commission

OTHER

Sponsor Role collaborator

University Hospital, Geneva

OTHER

Sponsor Role lead

Responsible Party

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Stephen Harbarth

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Geneva University Hospitals

Geneva, , Switzerland

Site Status

Countries

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Switzerland

References

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Lee AS, Cooper BS, Malhotra-Kumar S, Chalfine A, Daikos GL, Fankhauser C, Carevic B, Lemmen S, Martinez JA, Masuet-Aumatell C, Pan A, Phillips G, Rubinovitch B, Goossens H, Brun-Buisson C, Harbarth S; MOSAR WP4 Study Group. Comparison of strategies to reduce meticillin-resistant Staphylococcus aureus rates in surgical patients: a controlled multicentre intervention trial. BMJ Open. 2013 Sep 19;3(9):e003126. doi: 10.1136/bmjopen-2013-003126.

Reference Type DERIVED
PMID: 24056477 (View on PubMed)

Other Identifiers

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LSHP-CT-037940

Identifier Type: -

Identifier Source: secondary_id

LSHP-CT-037940

Identifier Type: -

Identifier Source: org_study_id